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Very long-chain fatty acids: elongation, physiology and related disorders

Journal of biochemistry (Tokyo), 2012-11, Vol.152 (5), p.387-395

Kihara, Akio

2012

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Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS[S]

Journal of lipid research, 2020-06, Vol.61 (6), p.884-895

2020

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PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide

Nature communications, 2017-03, Vol.8 (1), p.14610-14610, Article 14610

2017

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Very long‐chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice

The FASEB journal, 2018-06, Vol.32 (6), p.2966-2978

2018

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Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

eLife, 2020-04, Vol.9

2020

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Enzyme Activities of the Ceramide Synthases CERS2–6 Are Regulated by Phosphorylation in the C-terminal Region

The Journal of biological chemistry, 2016-04, Vol.291 (14), p.7477-7487

2016

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Alteration of epidermal lipid composition as a result of deficiency in the magnesium transporter Nipal4

Journal of lipid research, 2024-06, Vol.65 (6), p.100550, Article 100550

2024

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Signaling Events of the Rim101 Pathway Occur at the Plasma Membrane in a Ubiquitination-Dependent Manner

Molecular and cellular biology, 2014-09, Vol.34 (18), p.3525-3534

2014

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Formation of fatty alcohols—components of meibum lipids—by the fatty acyl‐CoA reductase FAR2 is essential for dry eye prevention

The FASEB journal, 2022-04, Vol.36 (4), p.e22216-n/a

2022

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The Rim101 pathway contributes to ER stress adaptation through sensing the state of plasma membrane

Biochemical journal, 2017-01, Vol.474 (1), p.51-63

2017

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ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis

Proceedings of the National Academy of Sciences - PNAS, 2010-10, Vol.107 (43), p.18439-18444

2010

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Two modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycle

PloS one, 2014-07, Vol.9 (7), p.e101823-e101823

2014

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Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

Biochemical journal, 2005-08, Vol.390 (Pt 1), p.263-271

2005

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Membrane Protein Rim21 Plays a Central Role in Sensing Ambient pH in Saccharomyces cerevisiae

The Journal of biological chemistry, 2012-11, Vol.287 (46), p.38473-38481

2012

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N-glycosylation of Rim21 at an Unconventional Site Fine-tunes Its Behavior in the Plasma Membrane

Cell Structure and Function, 2020, Vol.45(1), pp.1-8

2020

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Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid[S]

Journal of lipid research, 2014-03, Vol.55 (3), p.524-530

2014

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Dual Functions of the Trans-2-Enoyl-CoA Reductase TER in the Sphingosine 1-Phosphate Metabolic Pathway and in Fatty Acid Elongation

The Journal of biological chemistry, 2014-09, Vol.289 (36), p.24736-24748

2014

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Biochemical characterization of the very long-chain fatty acid elongase ELOVL7

FEBS letters, 2011-10, Vol.585 (20), p.3337-3341

2011

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The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways

The Journal of biological chemistry, 2017-09, Vol.292 (37), p.15538-15551

2017

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Decreased Skin Barrier Lipid Acylceramide and Differentiation-Dependent Gene Expression in Ichthyosis Gene Nipal4-Knockout Mice

Journal of investigative dermatology, 2018-04, Vol.138 (4), p.741-749

2018

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Impaired Epidermal Permeability Barrier in Mice Lacking Elovl1, the Gene Responsible for Very-Long-Chain Fatty Acid Production

Molecular and Cellular Biology, 2013-07, Vol.33 (14), p.2787-2796

2013

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Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids

Nature communications, 2014-10, Vol.5 (1), p.5338-5338, Article 5338

2014

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Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system

Molecular biology of the cell, 2012-12, Vol.23 (23), p.4543-4551

2012

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Mechanistic Details of Early Steps in Coenzyme Q Biosynthesis Pathway in Yeast

Cell chemical biology, 2016-10, Vol.23 (10), p.1241-1250

2016

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Palmitoylated calnexin is a key component of the ribosome-translocon complex

The EMBO journal, 2012-04, Vol.31 (7), p.1823-1835

2012

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Very long-chain fatty acids: elongation, physiology and related disorders

Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS[S]

PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide

Very long‐chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice

Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

Enzyme Activities of the Ceramide Synthases CERS2–6 Are Regulated by Phosphorylation in the C-terminal Region

Alteration of epidermal lipid composition as a result of deficiency in the magnesium transporter Nipal4

Signaling Events of the Rim101 Pathway Occur at the Plasma Membrane in a Ubiquitination-Dependent Manner

Formation of fatty alcohols—components of meibum lipids—by the fatty acyl‐CoA reductase FAR2 is essential for dry eye prevention

The Rim101 pathway contributes to ER stress adaptation through sensing the state of plasma membrane

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis

Two modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycle

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

Membrane Protein Rim21 Plays a Central Role in Sensing Ambient pH in Saccharomyces cerevisiae

N-glycosylation of Rim21 at an Unconventional Site Fine-tunes Its Behavior in the Plasma Membrane

Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid[S]

Dual Functions of the Trans-2-Enoyl-CoA Reductase TER in the Sphingosine 1-Phosphate Metabolic Pathway and in Fatty Acid Elongation

Biochemical characterization of the very long-chain fatty acid elongase ELOVL7

The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways

Decreased Skin Barrier Lipid Acylceramide and Differentiation-Dependent Gene Expression in Ichthyosis Gene Nipal4-Knockout Mice

Impaired Epidermal Permeability Barrier in Mice Lacking Elovl1, the Gene Responsible for Very-Long-Chain Fatty Acid Production

Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids

Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system

Mechanistic Details of Early Steps in Coenzyme Q Biosynthesis Pathway in Yeast

Palmitoylated calnexin is a key component of the ribosome-translocon complex

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