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Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts

Journal of medicinal chemistry, 2015-12, Vol.58 (23), p.9334-9344

2015

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Total Synthesis and Structure Confirmation of trans-Anhydromevalonate-5-phosphate, a Key Biosynthetic Intermediate of the Archaeal Mevalonate Pathway

Journal of natural products (Washington, D.C.), 2021-10, Vol.84 (10), p.2749-2754

2021

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Design, Synthesis, and Preclinical Evaluation of New 5,6- (or 6,7-) Disubstituted-2-(fluorophenyl)quinolin-4-one Derivatives as Potent Antitumor Agents

Journal of medicinal chemistry, 2010-11, Vol.53 (22), p.8047-8058

2010

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Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01

ACS chemical neuroscience, 2012-06, Vol.3 (6), p.451-458

2012

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Novel Immunomodulator FTY720 Is Phosphorylated in Rats and Humans To Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer

Journal of medicinal chemistry, 2005-08, Vol.48 (16), p.5373-5377

2005

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Antineoplastic Agents. 465. Structural Modification of Resveratrol: Sodium Resverastatin Phosphate

Journal of medicinal chemistry, 2002-06, Vol.45 (12), p.2534-2542

2002

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Calyculins and related marine natural products as serine-threonine protein phosphatase PP1 and PP2A inhibitors and total syntheses of calyculin A, B, and C

Marine Drugs, 2010-01, Vol.8 (1), p.122-172

2010

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Enzymatically Activated cycloSal-d4T-monophosphates: The Third Generation of cycloSal-Pronucleotides

Journal of medicinal chemistry, 2007-04, Vol.50 (7), p.1658-1667

2007

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Systemic Delivery of Small Interfering RNA by Use of Targeted Polycation Liposomes for Cancer Therapy

Biological and Pharmaceutical Bulletin, 2013/02/01, Vol.36(2), pp.287-291

2013

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Duplex Formation of the Simplified Nucleic Acid GNA

Chembiochem : a European journal of chemical biology, 2007-05, Vol.8 (8), p.927-932

2007

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Cleavage of Phosphodiesters and of DNA by a Bis(guanidinium)naphthol Acting as a Metal-Free Anion Receptor

Chembiochem : a European journal of chemical biology, 2011-05, Vol.12 (8), p.1223-1229

2011

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Ionic Liquids and Proteases: A Clean Alliance for Semisynthesis

Chembiochem : a European journal of chemical biology, 2008-06, Vol.9 (9), p.1493-1499

2008

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Fatty Alcohol Phosphates are Subtype-Selective Agonists and Antagonists of Lysophosphatidic Acid Receptors

Molecular pharmacology, 2003-05, Vol.63 (5), p.1032-1042

2003

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A Prodrug Approach toward the Development of Water Soluble Fluoroquinolones and Structure−Activity Relationships of Quinoline-3-carboxylic Acids

Journal of medicinal chemistry, 2004-09, Vol.47 (19), p.4693-4709

2004

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Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates and Diphosphates: A Potential Route to New Bone Antiresorption and Antiparasitic Agents

Journal of medicinal chemistry, 2002-05, Vol.45 (11), p.2185-2196

2002

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Uracil-Catalyzed Synthesis of Acetyl Phosphate: A Photochemical Driver for Protometabolism

Chembiochem : a European journal of chemical biology, 2010-02, Vol.11 (3), p.383-387

Hagan Jr, William J.

2010

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Preparation and characterization of niosomes containing ribavirin for liver targeting

Drug delivery, 2010-07, Vol.17 (5), p.282-287

2010

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Topical buparvaquone formulations for the treatment of cutaneous leishmaniasis

Journal of pharmacy and pharmacology, 2007-01, Vol.59 (1), p.41-49

2007

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SAR and X-ray. A New Approach Combining Fragment-Based Screening and Rational Drug Design: Application to the Discovery of Nanomolar Inhibitors of Src SH2

Journal of medicinal chemistry, 2002-06, Vol.45 (12), p.2379-2387

2002

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Skin Permeation Enhancement of Ascorbyl Palmitate by Liposomal Hydrogel (Lipogel) Formulation and Electrical Assistance

Biological and Pharmaceutical Bulletin, 2007, Vol.30(2), pp.393-396

2007

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Examination of Phosphoryl-Mimicking Functionalities within a Macrocyclic Grb2 SH2 Domain-Binding Platform

Journal of medicinal chemistry, 2005-06, Vol.48 (12), p.3945-3948

2005

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The Effect of a Phosphodiester Linking Group on Albumin Binding, Blood Half-Life, and Relaxivity of Intravascular Diethylenetriaminepentaacetato Aquo Gadolinium(III) MRI Contrast Agents

Journal of medicinal chemistry, 2002-08, Vol.45 (16), p.3465-3474

2002

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cycloSal-Pronucleotides of 2‘-Fluoro-ara- and 2‘-Fluoro-ribo-2‘,3‘- dideoxyadenosine as a Strategy to Bypass a Metabolic Blockade

Journal of medicinal chemistry, 1999-05, Vol.42 (9), p.1615-1624

1999

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Swinhoeiamide A, a New Highly Active Calyculin Derivative from the Marine Sponge Theonella swinhoei

Journal of natural products (Washington, D.C.), 2002-08, Vol.65 (8), p.1168-1172

2002

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Development of Water-Soluble Prodrugs of the HIV-1 Protease Inhibitor KNI-727: Importance of the Conversion Time for Higher Gastrointestinal Absorption of Prodrugs Based on Spontaneous Chemical Cleavage

Journal of medicinal chemistry, 2003-09, Vol.46 (19), p.4124-4135

2003

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Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts

Total Synthesis and Structure Confirmation of trans-Anhydromevalonate-5-phosphate, a Key Biosynthetic Intermediate of the Archaeal Mevalonate Pathway

Design, Synthesis, and Preclinical Evaluation of New 5,6- (or 6,7-) Disubstituted-2-(fluorophenyl)quinolin-4-one Derivatives as Potent Antitumor Agents

Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01

Novel Immunomodulator FTY720 Is Phosphorylated in Rats and Humans To Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer

Antineoplastic Agents. 465. Structural Modification of Resveratrol: Sodium Resverastatin Phosphate

Calyculins and related marine natural products as serine-threonine protein phosphatase PP1 and PP2A inhibitors and total syntheses of calyculin A, B, and C

Enzymatically Activated cycloSal-d4T-monophosphates: The Third Generation of cycloSal-Pronucleotides

Systemic Delivery of Small Interfering RNA by Use of Targeted Polycation Liposomes for Cancer Therapy

Duplex Formation of the Simplified Nucleic Acid GNA

Cleavage of Phosphodiesters and of DNA by a Bis(guanidinium)naphthol Acting as a Metal-Free Anion Receptor

Ionic Liquids and Proteases: A Clean Alliance for Semisynthesis

Fatty Alcohol Phosphates are Subtype-Selective Agonists and Antagonists of Lysophosphatidic Acid Receptors

A Prodrug Approach toward the Development of Water Soluble Fluoroquinolones and Structure−Activity Relationships of Quinoline-3-carboxylic Acids

Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates and Diphosphates: A Potential Route to New Bone Antiresorption and Antiparasitic Agents

Uracil-Catalyzed Synthesis of Acetyl Phosphate: A Photochemical Driver for Protometabolism

Preparation and characterization of niosomes containing ribavirin for liver targeting

Topical buparvaquone formulations for the treatment of cutaneous leishmaniasis

SAR and X-ray. A New Approach Combining Fragment-Based Screening and Rational Drug Design: Application to the Discovery of Nanomolar Inhibitors of Src SH2

Skin Permeation Enhancement of Ascorbyl Palmitate by Liposomal Hydrogel (Lipogel) Formulation and Electrical Assistance

Examination of Phosphoryl-Mimicking Functionalities within a Macrocyclic Grb2 SH2 Domain-Binding Platform

The Effect of a Phosphodiester Linking Group on Albumin Binding, Blood Half-Life, and Relaxivity of Intravascular Diethylenetriaminepentaacetato Aquo Gadolinium(III) MRI Contrast Agents

cycloSal-Pronucleotides of 2‘-Fluoro-ara- and 2‘-Fluoro-ribo-2‘,3‘- dideoxyadenosine as a Strategy to Bypass a Metabolic Blockade

Swinhoeiamide A, a New Highly Active Calyculin Derivative from the Marine Sponge Theonella swinhoei

Development of Water-Soluble Prodrugs of the HIV-1 Protease Inhibitor KNI-727: Importance of the Conversion Time for Higher Gastrointestinal Absorption of Prodrugs Based on Spontaneous Chemical Cleavage

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