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Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.2790-2818

2017

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Die Erschließung von Wirkstoffmetaboliten durch übergangsmetallkatalysierte C-H-Oxidation: die Leber als Inspiration für die Synthese

Angewandte Chemie, 2016-11, Vol.128 (46), p.14430-14451

2016

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Optimization of Activity, Selectivity, and Liability Profiles in 5‑Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)‑2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo‑5H‑pyrrolo[3,4‑b]pyridin-6(7H)‑yl)‑N,N‑dimethylacetamide (BMS-767778)

Journal of medicinal chemistry, 2013-09, Vol.56 (18), p.7343-7357

2013

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Natural products on demand

Nature chemistry, 2014, Vol.6 (6), p.460-461

Hamann, Lawrence G.

2014

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Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines

Journal of medicinal chemistry, 1998-02, Vol.41 (4), p.623-639

1998

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The 2 nd Alpine Winter Conference on Medicinal and Synthetic Chemistry

ChemMedChem, 2021-08, Vol.16 (15), p.2417-2423

2021

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A scalable synthesis of (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-car b oxylic acid

Tetrahedron letters, 2013-12, Vol.54 (49), p.6722-6724

2013

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ChemInform Abstract: Accessing Drug Metabolites via Transition‐Metal Catalyzed C—H Oxidation: The Liver as Synthetic Inspiration

ChemInform, 2016-12, Vol.47 (51), p.no-no

2016

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Die Erschließung von Wirkstoffmetaboliten durch übergangsmetallkatalysierte C‐H‐Oxidation: die Leber als Inspiration für die Synthese

Angewandte Chemie, 2016-11, Vol.128 (46), p.14430-14451

2016

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Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate ( Sa )-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5 H -pyrrolo[3,4- b ]pyridin-6(7 H )-yl)- N , N -dimethylacetamide (BMS-767778)

Journal of medicinal chemistry, 2013-09, Vol.56 (18), p.7343-7357

2013

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ChemInform Abstract: Regioselective Synthesis and Slow-Release Suzuki-Miyaura Cross-Coupling of MIDA Boronate-Functionalized Isoxazoles and Triazoles

ChemInform, 2012-04, Vol.43 (15), p.no-no

2012

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ChemInform Abstract: One-Pot C-N/C-C Cross-Coupling of Methyliminodiacetic Acid Boronyl Arenes Enabled by Protective Enolization

ChemInform, 2013-03, Vol.44 (12), p.no-no

2013

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ChemInform Abstract: Sustainable Practices in Medicinal Chemistry: Current State and Future Directions

ChemInform, 2013-10, Vol.44 (40), p.no-no

2013

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An efficient, highly stereoselective synthesis of (Z)-16.alpha.-hydroxy-17-ethylidene steroids

Journal of organic chemistry, 1992-06, Vol.57 (12), p.3507-3509

1992

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Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.2790-2818

2017

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Benzodiazepine-based selective inhibitors of mitochondrial F 1 F 0 ATP hydrolase

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (4), p.1031-1034

2004

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N -[1-Aryl-2-(1-imidazolo)ethyl]-guanidine derivatives as potent inhibitors of the bovine mitochondrial F 1 F 0 ATP hydrolase

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (4), p.1027-1030

2004

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Fourth Winter Conference on Medicinal and Bioorganic Chemistry. Part 2

Medicinal research reviews (Print), 2001, Vol.21 (6)

2001

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Cofactor-specific modulation of 11beta-hydroxysteroid dehydrogenase 1 inhibitor potency

Biochimica et biophysica acta, 2007-09, Vol.1774 (9), p.1184

2007

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Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1

Bioorganic & medicinal chemistry letters, 2008-06, Vol.18 (11), p.3168

2008

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Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)-2 H-pyrano[3,2- g]quinolin-2-one

Bioorganic & medicinal chemistry letters, 1999, Vol.9 (7), p.1003-1008

1999

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Chapter 1 - The Discovery of the Dipeptidyl Peptidase-4 (DPP4) Inhibitor Onglyza™: From Concept to Market

Accounts in Drug Discovery: Case Studies in Medicinal Chemistry, 2011, p.1-24

2011

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ChemInform Abstract: An Efficient, Stereospecific Synthesis of the Dimer-Selective Retinoid X Receptor Modulator (2E,4E,6Z)-7- [5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-(n-propyloxy)naphthalen-3-yl] -3-methylocta-2,4,6-trienoic Acid

ChemInform, 2000-09, Vol.31 (36), p.no-no

Hamann, Lawrence G.

2000

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Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer

Die Erschließung von Wirkstoffmetaboliten durch übergangsmetallkatalysierte C-H-Oxidation: die Leber als Inspiration für die Synthese

Optimization of Activity, Selectivity, and Liability Profiles in 5‑Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)‑2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo‑5H‑pyrrolo[3,4‑b]pyridin-6(7H)‑yl)‑N,N‑dimethylacetamide (BMS-767778)

Natural products on demand

Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines

The 2 nd Alpine Winter Conference on Medicinal and Synthetic Chemistry

A scalable synthesis of (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-car b oxylic acid

ChemInform Abstract: Accessing Drug Metabolites via Transition‐Metal Catalyzed C—H Oxidation: The Liver as Synthetic Inspiration

Die Erschließung von Wirkstoffmetaboliten durch übergangsmetallkatalysierte C‐H‐Oxidation: die Leber als Inspiration für die Synthese

Erratum: Corrigendum: SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

Erratum: Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice

Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate ( Sa )-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5 H -pyrrolo[3,4- b ]pyridin-6(7 H )-yl)- N , N -dimethylacetamide (BMS-767778)

ChemInform Abstract: Regioselective Synthesis and Slow-Release Suzuki-Miyaura Cross-Coupling of MIDA Boronate-Functionalized Isoxazoles and Triazoles

ChemInform Abstract: One-Pot C-N/C-C Cross-Coupling of Methyliminodiacetic Acid Boronyl Arenes Enabled by Protective Enolization

ChemInform Abstract: Sustainable Practices in Medicinal Chemistry: Current State and Future Directions

An efficient, highly stereoselective synthesis of (Z)-16.alpha.-hydroxy-17-ethylidene steroids

Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer

Benzodiazepine-based selective inhibitors of mitochondrial F 1 F 0 ATP hydrolase

N -[1-Aryl-2-(1-imidazolo)ethyl]-guanidine derivatives as potent inhibitors of the bovine mitochondrial F 1 F 0 ATP hydrolase

Fourth Winter Conference on Medicinal and Bioorganic Chemistry. Part 2

Cofactor-specific modulation of 11beta-hydroxysteroid dehydrogenase 1 inhibitor potency

Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1

Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)-2 H-pyrano[3,2- g]quinolin-2-one

Chapter 1 - The Discovery of the Dipeptidyl Peptidase-4 (DPP4) Inhibitor Onglyza™: From Concept to Market

ChemInform Abstract: An Efficient, Stereospecific Synthesis of the Dimer-Selective Retinoid X Receptor Modulator (2E,4E,6Z)-7- [5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-(n-propyloxy)naphthalen-3-yl] -3-methylocta-2,4,6-trienoic Acid

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