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Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: Reducing cytotoxicity by structural simplification

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.733-736

2013

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Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2′ O)-methyltransferase

Bioorganic & medicinal chemistry, 2007-12, Vol.15 (24), p.7795-7802

2007

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Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9

Nature chemical biology, 2005-08, Vol.1 (3), p.143-145

2005

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Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases

Nature chemical biology, 2013-03, Vol.9 (3), p.136

2013

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Induced production of mycotoxins in an endophytic fungus from the medicinal plant Datura stramonium L

Bioorganic & medicinal chemistry letters, 2012-10, Vol.22 (20), p.6397-6400

2012

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Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2103-2105

2010

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Effects of COMT inhibitors on striatal dopamine metabolism: a microdialysis study

Brain research, 1992-08, Vol.587 (2), p.241-249

1992

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Induction of MHC class I-related chain B (MICB) by 5-aza-2′-deoxycytidine

Biochemical and biophysical research communications, 2008-06, Vol.370 (4), p.578-583

2008

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High-resolution structures of the SARS-CoV-2 2'- O -methyltransferase reveal strategies for structure-based inhibitor design

Science signaling, 2020-09, Vol.13 (651)

2020

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Inhibition of human catechol- O-methyltransferase (COMT)-mediated O-methylation of catechol estrogens by major polyphenolic components present in coffee

The Journal of steroid biochemistry and molecular biology, 2009, Vol.113 (1), p.65-74

2009

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Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

Nature structural & molecular biology, 2009-03, Vol.16 (3), p.312-317

2009

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The importance of non-histone protein methylation in cancer therapy

Nature reviews. Molecular cell biology, 2019-10, Vol.20 (10), p.569

2019

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Proteomics profiling of arginine methylation defines PRMT5 substrate specificity

Science signaling, 2019-04, Vol.12 (575)

2019

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Blocking the histone lysine 79 methyltransferase DOT1L alleviates renal fibrosis through inhibition of renal fibroblast activation and epithelial‐mesenchymal transition

The FASEB journal, 2019-11, Vol.33 (11), p.11941-11958

2019

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DNA methylation regulates neuronal glutamatergic synaptic scaling

Science signaling, 2015-06, Vol.8 (382), p.ra61

2015

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Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol- O-methyltransferase inhibitor

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2614-2616

2010

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Entacapone, a catechol- O -methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat model of Parkinson's disease induced by Japanese encephalitis virus

Brain research, 2010-01, Vol.1309, p.110-115

2010

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Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

Journal of molecular biology, 2010-07, Vol.400 (1), p.1-7

2010

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Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

Nature biotechnology, 2008-07, Vol.26 (7), p.795-797

2008

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Inhibition of H3K9 methyltransferase G9a induces autophagy and apoptosis in oral squamous cell carcinoma

Biochemical and biophysical research communications, 2015-03, Vol.459 (1), p.10-17

2015

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Microplate screening assay to identify inhibitors of human catechol-O-methyltransferase

Analytical biochemistry, 2004-08, Vol.331 (1), p.198-200

2004

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Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13

Bioorganic & medicinal chemistry letters, 2012-06, Vol.22 (12), p.4049-4054

2012

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Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: Reducing cytotoxicity by structural simplification

Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2′ O)-methyltransferase

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases

Induced production of mycotoxins in an endophytic fungus from the medicinal plant Datura stramonium L

Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases

Effects of COMT inhibitors on striatal dopamine metabolism: a microdialysis study

Induction of MHC class I-related chain B (MICB) by 5-aza-2′-deoxycytidine

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

High-resolution structures of the SARS-CoV-2 2'- O -methyltransferase reveal strategies for structure-based inhibitor design

Inhibition of human catechol- O-methyltransferase (COMT)-mediated O-methylation of catechol estrogens by major polyphenolic components present in coffee

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

The importance of non-histone protein methylation in cancer therapy

Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase

Proteomics profiling of arginine methylation defines PRMT5 substrate specificity

Blocking the histone lysine 79 methyltransferase DOT1L alleviates renal fibrosis through inhibition of renal fibroblast activation and epithelial‐mesenchymal transition

DNA methylation regulates neuronal glutamatergic synaptic scaling

Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol- O-methyltransferase inhibitor

Entacapone, a catechol- O -methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat model of Parkinson's disease induced by Japanese encephalitis virus

Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

Inhibition of H3K9 methyltransferase G9a induces autophagy and apoptosis in oral squamous cell carcinoma

Microplate screening assay to identify inhibitors of human catechol-O-methyltransferase

Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13

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