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Observing a DNA Polymerase Choose Right from Wrong

Cell, 2013-07, Vol.154 (1), p.157-168

2013

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Eukaryotic Base Excision Repair: New Approaches Shine Light on Mechanism

Annual review of biochemistry, 2019-06, Vol.88 (1), p.137-162

2019

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Capturing snapshots of APE1 processing DNA damage

Nature structural & molecular biology, 2015-11, Vol.22 (11), p.924-931

2015

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Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

Nature (London), 2015-01, Vol.517 (7536), p.635-639

2015

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Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism

Structure (London), 2016-11, Vol.24 (11), p.1863-1875

2016

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Substrate Channeling in Mammalian Base Excision Repair Pathways: Passing the Baton

The Journal of biological chemistry, 2010-12, Vol.285 (52), p.40479-40488

2010

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Time-lapse crystallography snapshots of a double-strand break repair polymerase in action

Nature communications, 2017-08, Vol.8 (1), p.253-11, Article 253

2017

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Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

Nature communications, 2021-08, Vol.12 (1), p.5055-11, Article 5055

2021

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Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide

Nature communications, 2021-04, Vol.12 (1), p.2059-12, Article 2059

2021

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Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse

Proceedings of the National Academy of Sciences - PNAS, 2015-09, Vol.112 (38), p.E5228-E5236

2015

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DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion

Nucleic acids research, 2013-02, Vol.41 (3), p.1848-1858

2013

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DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine

Mutation research, 2010-11, Vol.703 (1), p.18-23

2010

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DNA Sequence Context Effects on the Glycosylase Activity of Human 8-Oxoguanine DNA Glycosylase

The Journal of biological chemistry, 2012-10, Vol.287 (44), p.36702-36710

2012

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A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition

Nucleic acids research, 2019-04, Vol.47 (6), p.3197-3207

2019

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Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly

Structure (London), 2012-11, Vol.20 (11), p.1829-1837

2012

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Magnesium-Induced Assembly of a Complete DNA Polymerase Catalytic Complex

Structure (London), 2006-04, Vol.14 (4), p.757-766

2006

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Phylogenetic analysis and evolutionary origins of DNA polymerase X-family members

DNA repair, 2014-10, Vol.22, p.77-88

2014

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Hiding in Plain Sight: The Bimetallic Magnesium Covalent Bond in Enzyme Active Sites

Inorganic chemistry, 2017-01, Vol.56 (1), p.313-320

2017

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Impact of Ribonucleotide Backbone on Translesion Synthesis and Repair of 7,8-Dihydro-8-oxoguanine

The Journal of biological chemistry, 2016-11, Vol.291 (46), p.24314-24323

2016

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Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion

Proceedings of the National Academy of Sciences - PNAS, 2012-01, Vol.109 (1), p.113-118

2012

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Base Excision Repair of Tandem Modifications in a Methylated CpG Dinucleotide

The Journal of biological chemistry, 2014-05, Vol.289 (20), p.13996-14008

2014

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DNA polymerase β: Closing the gap between structure and function

DNA repair, 2020-09, Vol.93, p.102910-102910, Article 102910

Beard, William A.

2020

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Structure and Mechanism of DNA Polymerase β

Biochemistry (Easton), 2014-05, Vol.53 (17), p.2768-2780

2014

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Inhibition of HIV-1 reverse transcriptase-catalyzed synthesis by intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide adducts

PloS one, 2013-09, Vol.8 (9), p.e72131

2013

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Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site

Nature structural & molecular biology, 2010-07, Vol.17 (7), p.889-890

2010

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Observing a DNA Polymerase Choose Right from Wrong

Eukaryotic Base Excision Repair: New Approaches Shine Light on Mechanism

Capturing snapshots of APE1 processing DNA damage

Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism

Substrate Channeling in Mammalian Base Excision Repair Pathways: Passing the Baton

Time-lapse crystallography snapshots of a double-strand break repair polymerase in action

Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide

Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse

DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion

DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine

DNA Sequence Context Effects on the Glycosylase Activity of Human 8-Oxoguanine DNA Glycosylase

A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition

Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly

Magnesium-Induced Assembly of a Complete DNA Polymerase Catalytic Complex

Phylogenetic analysis and evolutionary origins of DNA polymerase X-family members

Hiding in Plain Sight: The Bimetallic Magnesium Covalent Bond in Enzyme Active Sites

Impact of Ribonucleotide Backbone on Translesion Synthesis and Repair of 7,8-Dihydro-8-oxoguanine

Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion

Base Excision Repair of Tandem Modifications in a Methylated CpG Dinucleotide

DNA polymerase β: Closing the gap between structure and function

Structure and Mechanism of DNA Polymerase β

Inhibition of HIV-1 reverse transcriptase-catalyzed synthesis by intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide adducts

Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site

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