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Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindles

PLoS biology, 2023-10, Vol.21 (10), p.e3002339-e3002339

2023

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The Adenomatous Polyposis Coli Protein Unambiguously Localizes to Microtubule Plus Ends and Is Involved in Establishing Parallel Arrays of Microtubule Bundles in Highly Polarized Epithelial Cells

The Journal of cell biology, 2002-06, Vol.157 (6), p.1041-1048

2002

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Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel

Science translational medicine, 2021-09, Vol.13 (610), p.eabd4811

2021

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CENP-E Inhibition Induces Chromosomal Instability and Synergizes with Diverse Microtubule-Targeting Agents in Breast Cancer

Cancer research (Chicago, Ill.), 2024-08, Vol.84 (16), p.2674-2689

2024

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Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS-STING Signaling in Triple-Negative Breast Cancer

Molecular cancer therapeutics, 2021-12, Vol.20 (12), p.2553-2567

2021

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Chromosome Missegregation as a Modulator of Radiation Sensitivity

Seminars in radiation oncology, 2022-01, Vol.32 (1), p.54-63

2022

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High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer

Scientific reports, 2018-11, Vol.8 (1), p.17239-13, Article 17239

2018

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Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer

Cancer research communications, 2023-01, Vol.3 (1), p.54-65

2023

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Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindles

PLoS biology, 2023-10, Vol.21 (10)

2023

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Determining the Landscape of CIN in Breast Cancer and Methods to Leverage CIN as a Therapeutic Target

Tucker, John B

2023

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Abstract 2248: Paclitaxel-induced micronucleation activates pro-inflammatory cGAS/STING signaling in triple negative breast cancer

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.2248-2248

2020

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Abstract B018: A high-throughput screen identifies HSP90 inhibitors as potent therapeutics across multiple clinically representative organoid models of advanced prostate cancer

Cancer research (Chicago, Ill.), 2018-08, Vol.78 (16_Supplement), p.B018-B018

2018

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A cell surface-associated centrosomal layer of microtubule-organizing material in the inner pillar cell of the mouse cochlea

Journal of cell science, 1992-06, Vol.102 (2), p.215-226

1992

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Non-centrosomal microtubule-organising centres in cold-treated cultured Drosophila cells

Cell motility and the cytoskeleton, 2006-02, Vol.63 (2), p.88-100

2006

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The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly

The Journal of cell biology, 2002-06, Vol.157 (6), p.1041

2002

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Positioning and capture of cell surface-associated microtubules in epithelial tendon cells that differentiate in primary embryonic Drosophila cell cultures

Cell motility and the cytoskeleton, 2004-03, Vol.57 (3), p.175-185

2004

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Microtubule polarities indicate that nucleation and capture of microtubules occurs at cell surfaces in Drosophila

The Journal of cell biology, 1989-04, Vol.108 (4), p.1445-1452

1989

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Three microtubule-organizing centres collaborate in a mouse cochlear epithelial cell during supracellularly coordinated control of microtubule positioning

Journal of cell science, 1995-01, Vol.108 ( Pt 1) (1), p.37-50

1995

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Nucleation and capture of large cell surface-associated microtubule arrays that are not located near centrosomes in certain cochlear epithelial cells

American journal of anatomy, 1998-01, Vol.192 (1), p.119-130

1998

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Reorganization of the centrosome and associated microtubules during the morphogenesis of a mouse cochlear epithelial cell

Journal of cell science, 1994-02, Vol.107 (2), p.589-600

1994

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Formation of two microtubule-nucleating sites which perform differently during centrosomal reorganization in a mouse cochlear epithelial cell

Journal of cell science, 1995-04, Vol.108 ( Pt 4) (4), p.1333-1345

1995

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Spatial Organization of Microtubule-Organizing Centers and Microtubules

The Journal of cell biology, 1984-07, Vol.99 (1), p.55s-62s

Tucker, John B.

1984

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Taxol influences control of protofilament number at microtubule-nucleating sites in Drosophila

Journal of cell science, 1990-09, Vol.97 (1), p.101-107

1990

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Cytoskeletal integration in a highly ordered sensory epithelium in the organ of corti: Reponse to loss of cell partners in the bronx waltzer mouse

Brain cell biology, 1999-12, Vol.28 (12), p.1017

1999

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Spindle Microtubule Differentiation and Deployment during Micronuclear Mitosis in Paramecium

The Journal of cell biology, 1985-11, Vol.101 (5), p.1966-1976

1985

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Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindles

The Adenomatous Polyposis Coli Protein Unambiguously Localizes to Microtubule Plus Ends and Is Involved in Establishing Parallel Arrays of Microtubule Bundles in Highly Polarized Epithelial Cells

Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel

CENP-E Inhibition Induces Chromosomal Instability and Synergizes with Diverse Microtubule-Targeting Agents in Breast Cancer

Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS-STING Signaling in Triple-Negative Breast Cancer

Chromosome Missegregation as a Modulator of Radiation Sensitivity

High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer

Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer

Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindles

Determining the Landscape of CIN in Breast Cancer and Methods to Leverage CIN as a Therapeutic Target

Abstract 2248: Paclitaxel-induced micronucleation activates pro-inflammatory cGAS/STING signaling in triple negative breast cancer

Abstract B018: A high-throughput screen identifies HSP90 inhibitors as potent therapeutics across multiple clinically representative organoid models of advanced prostate cancer

A cell surface-associated centrosomal layer of microtubule-organizing material in the inner pillar cell of the mouse cochlea

Non-centrosomal microtubule-organising centres in cold-treated cultured Drosophila cells

The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly

Positioning and capture of cell surface-associated microtubules in epithelial tendon cells that differentiate in primary embryonic Drosophila cell cultures

Microtubule polarities indicate that nucleation and capture of microtubules occurs at cell surfaces in Drosophila

Three microtubule-organizing centres collaborate in a mouse cochlear epithelial cell during supracellularly coordinated control of microtubule positioning

Nucleation and capture of large cell surface-associated microtubule arrays that are not located near centrosomes in certain cochlear epithelial cells

Reorganization of the centrosome and associated microtubules during the morphogenesis of a mouse cochlear epithelial cell

Formation of two microtubule-nucleating sites which perform differently during centrosomal reorganization in a mouse cochlear epithelial cell

Spatial Organization of Microtubule-Organizing Centers and Microtubules

Taxol influences control of protofilament number at microtubule-nucleating sites in Drosophila

Cytoskeletal integration in a highly ordered sensory epithelium in the organ of corti: Reponse to loss of cell partners in the bronx waltzer mouse

Spindle Microtubule Differentiation and Deployment during Micronuclear Mitosis in Paramecium

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