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Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice

Gastroenterology (New York, N.Y. 1943), 2015-12, Vol.149 (7), p.1884-1895.e4

2015

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Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia

Journal of ethnopharmacology, 2022-05, Vol.289, p.115021, Article 115021

2022

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Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways

The Journal of nutritional biochemistry, 2017-03, Vol.41, p.124-136

2017

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Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases

Journal of medicinal chemistry, 2019-05, Vol.62 (10), p.4783-4814

2019

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Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice

Gastroenterology (New York, N.Y. 1943), 2017-07, Vol.153 (1), p.277-291.e19

2017

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IRS1 promotes thyroid cancer metastasis through EMT and PI3K/AKT pathways

Clinical endocrinology (Oxford), 2024-03, Vol.100 (3), p.284-293

2024

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Chrysin induces death of prostate cancer cells by inducing ROS and ER stress

Journal of cellular physiology, 2017-12, Vol.232 (12), p.3786-3797

2017

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Inorganic pyrophosphatase 1 activates the phosphatidylinositol 3-kinase/Akt signaling to promote tumorigenicity and stemness properties in colorectal cancer

Cellular signalling, 2023-08, Vol.108, p.110693-110693, Article 110693

2023

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Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway

Cancer letters, 2014-02, Vol.343 (2), p.179-189

2014

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Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes

Gynecologic oncology, 2016-09, Vol.142 (3), p.548-556

2016

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C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits

Gastroenterology (New York, N.Y. 1943), 2016-05, Vol.150 (5), p.1183-1195.e16

2016

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Combining NanoKnife with M1 oncolytic virus enhances anticancer activity in pancreatic cancer

Cancer letters, 2021-04, Vol.502, p.9-24

2021

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Transforming growth factor alpha promotes osteosarcoma metastasis by ICAM-1 and PI3K/Akt signaling pathway

Biochemical pharmacology, 2014-06, Vol.89 (4), p.453-463

2014

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Anticancer mechanisms and clinical application of alkylphospholipids

Biochimica et biophysica acta, 2013-03, Vol.1831 (3), p.663-674

2013

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LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85

Cancer letters, 2018-04, Vol.420, p.38-48

2018

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The pathological significance of LOXL2 in pre-metastatic niche formation of HCC and its related molecular mechanism

European journal of cancer (1990), 2021-04, Vol.147, p.63-73

2021

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Mucin O-glycosylating enzyme GALNT2 facilitates the malignant character of glioma by activating the EGFR/PI3K/Akt/mTOR axis

Clinical science (1979), 2019-05, Vol.133 (10), p.1167

2019

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Tanshinone IIA combined with cisplatin synergistically inhibits non‐small‐cell lung cancer in vitro and in vivo via down‐regulating the phosphatidylinositol 3‐kinase/Akt signalling pathway

Phytotherapy research, 2019-09, Vol.33 (9), p.2298-2309

2019

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Knockdown of circHIPK3 Facilitates Temozolomide Sensitivity in Glioma by Regulating Cellular Behaviors Through miR-524-5p/KIF2A-Mediated PI3K/AKT Pathway

Cancer biotherapy & radiopharmaceuticals, 2021-09, Vol.36 (7), p.556

2021

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miR-221 regulates CD44 in hepatocellular carcinoma through the PI3K-AKT-mTOR pathway

Biochemical and biophysical research communications, 2017-06, Vol.487 (3), p.709-715

2017

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A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and induce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway

Journal of ethnopharmacology, 2022-01, Vol.283, p.114742-114742, Article 114742

2022

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Inhibition of phosphatidylinositide 3-kinase ameliorates antiproliferation by benzyl isothiocyanate in human colon cancer cells

Biochemical and biophysical research communications, 2017-09, Vol.491 (1), p.209-216

2017

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Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

ACS chemical biology, 2019-09, Vol.14 (9), p.2024-2034

2019

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Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3‑Kinase (PI3K) Inhibitors

Journal of medicinal chemistry, 2016-08, Vol.59 (15), p.7268-7274

2016

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Transglutaminase 3 suppresses proliferation and cisplatin resistance of cervical cancer cells by inactivation of the PI3K/AKT pathway

Naunyn-Schmiedeberg's archives of pharmacology, 2024-04, Vol.397 (4), p.2269-2280

2024

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Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice

Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia

Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways

Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases

Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice

IRS1 promotes thyroid cancer metastasis through EMT and PI3K/AKT pathways

Chrysin induces death of prostate cancer cells by inducing ROS and ER stress

Inorganic pyrophosphatase 1 activates the phosphatidylinositol 3-kinase/Akt signaling to promote tumorigenicity and stemness properties in colorectal cancer

Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway

Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes

C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits

Combining NanoKnife with M1 oncolytic virus enhances anticancer activity in pancreatic cancer

Transforming growth factor alpha promotes osteosarcoma metastasis by ICAM-1 and PI3K/Akt signaling pathway

Anticancer mechanisms and clinical application of alkylphospholipids

LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85

The pathological significance of LOXL2 in pre-metastatic niche formation of HCC and its related molecular mechanism

Mucin O-glycosylating enzyme GALNT2 facilitates the malignant character of glioma by activating the EGFR/PI3K/Akt/mTOR axis

Tanshinone IIA combined with cisplatin synergistically inhibits non‐small‐cell lung cancer in vitro and in vivo via down‐regulating the phosphatidylinositol 3‐kinase/Akt signalling pathway

Knockdown of circHIPK3 Facilitates Temozolomide Sensitivity in Glioma by Regulating Cellular Behaviors Through miR-524-5p/KIF2A-Mediated PI3K/AKT Pathway

miR-221 regulates CD44 in hepatocellular carcinoma through the PI3K-AKT-mTOR pathway

A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and induce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway

Inhibition of phosphatidylinositide 3-kinase ameliorates antiproliferation by benzyl isothiocyanate in human colon cancer cells

Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3‑Kinase (PI3K) Inhibitors

Transglutaminase 3 suppresses proliferation and cisplatin resistance of cervical cancer cells by inactivation of the PI3K/AKT pathway

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