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Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

Journal of medicinal chemistry, 2013-02, Vol.56 (3), p.593-624

2013

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Tumor inhibitory triazenes. 3. Dealkylation within an homologous series and its relation to antitumor activity

Journal of medicinal chemistry, 1984-07, Vol.27 (7), p.870-874

1984

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Synthesis and antitumor activity of 6-trifluoromethylcyclophosphamide and related compounds

Journal of medicinal chemistry, 1975-11, Vol.18 (11), p.1106-1110

1975

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Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Journal of medicinal chemistry, 2017-02, Vol.60 (4), p.1247-1261

2017

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Discovery of 6‑(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl‑1H‑indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia

Journal of medicinal chemistry, 2015-12, Vol.58 (24), p.9768-9772

2015

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Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3‑Kinase (PI3K)‑γ Inhibitors

Journal of medicinal chemistry, 2018-06, Vol.61 (12), p.5435-5441

2018

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Efficacious Inhaled PDE4 Inhibitors with Low Emetic Potential and Long Duration of Action for the Treatment of COPD

Journal of medicinal chemistry, 2014-06, Vol.57 (11), p.4661-4676

2014

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Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme‑1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9331-9345

2012

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Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases

Journal of medicinal chemistry, 2004-11, Vol.47 (24), p.5894-5911

2004

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Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1 H -indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia

Journal of medicinal chemistry, 2015-12, Vol.58 (24), p.9768-9772

2015

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Discovery of Potent Antagonists of Leukocyte Function-Associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction. 3. Amide (C-Ring) Structure−Activity Relationship and Improvement of Overall Properties of Arylthio Cinnamides

Journal of medicinal chemistry, 2001-08, Vol.44 (18), p.2913-2920

2001

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A nonpromoting phorbol from the Samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1

Journal of medicinal chemistry, 1992-05, Vol.35 (11), p.1978-1986

1992

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2-Aminopyridines as Highly Selective Inducible Nitric Oxide Synthase Inhibitors. Differential Binding Modes Dependent on Nitrogen Substitution

Journal of medicinal chemistry, 2004-06, Vol.47 (12), p.3320-3323

2004

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Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1 H -pyrazolo[3,4- d ]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases

Journal of medicinal chemistry, 2004-11, Vol.47 (24), p.5894-5911

2004

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The Squalestatins: Decarboxy and 4-Deoxy Analogues as Potent Squalene Synthase Inhibitors

Journal of medicinal chemistry, 1996-01, Vol.39 (1), p.207-216

1996

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The Squalestatins: Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in Vivo Evaluation of C3-Modified Analogues

Journal of medicinal chemistry, 1996-03, Vol.39 (7), p.1413-1422

1996

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Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

Tumor inhibitory triazenes. 3. Dealkylation within an homologous series and its relation to antitumor activity

Synthesis and antitumor activity of 6-trifluoromethylcyclophosphamide and related compounds

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Discovery of 6‑(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl‑1H‑indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia

Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3‑Kinase (PI3K)‑γ Inhibitors

Efficacious Inhaled PDE4 Inhibitors with Low Emetic Potential and Long Duration of Action for the Treatment of COPD

Discovery of the 3‑Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease

Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme‑1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation

Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases

Structure-Based Design of an Iminoheterocyclic β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates

Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1 H -indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia

Discovery of Potent Antagonists of Leukocyte Function-Associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction. 3. Amide (C-Ring) Structure−Activity Relationship and Improvement of Overall Properties of Arylthio Cinnamides

A nonpromoting phorbol from the Samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1

2-Aminopyridines as Highly Selective Inducible Nitric Oxide Synthase Inhibitors. Differential Binding Modes Dependent on Nitrogen Substitution

Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1 H -pyrazolo[3,4- d ]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases

The Squalestatins: Decarboxy and 4-Deoxy Analogues as Potent Squalene Synthase Inhibitors

The Squalestatins: Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in Vivo Evaluation of C3-Modified Analogues

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