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Species-conserved SYNGAP1 phenotypes associated with neurodevelopmental disorders

Molecular and cellular neuroscience, 2018-09, Vol.91, p.140-150

2018

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Ras superfamily GTPase activating proteins in cancer: Potential therapeutic targets?

European journal of medicinal chemistry, 2023-02, Vol.248, p.115104, Article 115104

2023

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IQGAP1 and its binding proteins control diverse biological functions

Cellular signalling, 2012-04, Vol.24 (4), p.826-834

2012

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Hydrolysis of Guanosine Triphosphate (GTP) by the Ras·GAP Protein Complex: Reaction Mechanism and Kinetic Scheme

The journal of physical chemistry. B, 2015-10, Vol.119 (40), p.12838-12845

2015

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P120-Ras GTPase activating protein (RasGAP): A multi-interacting protein in downstream signaling

Biochimie, 2009-03, Vol.91 (3), p.320-328

2009

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DAB2IP suppresses tumor malignancy by inhibiting GRP75-driven p53 ubiquitination in colon cancer

Cancer letters, 2022-04, Vol.532, p.215588-215588, Article 215588

2022

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IQGAP1 in cellular signaling: bridging the GAP

Trends in cell biology, 2006-05, Vol.16 (5), p.242-249

2006

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Large conformational changes in proteins: signaling and other functions

Current opinion in structural biology, 2010-04, Vol.20 (2), p.142-147

2010

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Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases

Nature cell biology, 2016-12, Vol.18 (12), p.1324-1335

2016

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IQGAP1 regulation and roles in cancer

Cellular signalling, 2009-10, Vol.21 (10), p.1471-1478

2009

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IQGAP1 regulates actin cytoskeleton organization in podocytes through interaction with nephrin

Cellular signalling, 2015-04, Vol.27 (4), p.867-877

2015

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Cell cycle-dependent phosphorylation of IQGAP is involved in assembly and stability of the contractile ring in fission yeast

Biochemical and biophysical research communications, 2021-01, Vol.534, p.1026-1032

2021

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Modeling the Role of G12V and G13V Ras Mutations in the Ras-GAP-Catalyzed Hydrolysis Reaction of Guanosine Triphosphate

Biochemistry (Easton), 2014-11, Vol.53 (45), p.7093-7099

2014

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SUMOylation of IQGAP1 promotes the development of colorectal cancer

Cancer letters, 2017-12, Vol.411, p.90-99

2017

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Active Rap1‐mediated inhibition of choroidal neovascularization requires interactions with IQGAP1 in choroidal endothelial cells

The FASEB journal, 2021-07, Vol.35 (7), p.e21642-n/a

2021

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Real-Time Monitoring of RAS Activity Using In Vitro and In-Cell NMR Spectroscopy

Methods in molecular biology (Clifton, N.J.), 2024, Vol.2797, p.237

2024

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Prenatal disruption of D1R-SynGAP complex causes cognitive deficits in adulthood

Progress in neuro-psychopharmacology & biological psychiatry, 2021-03, Vol.105, p.110122-110122, Article 110122

2021

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IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors

Nature medicine, 2013-05, Vol.19 (5), p.626-630

2013

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IQGAP1 and RNA Splicing in the Context of Head and Neck via Phosphoproteomics

Journal of proteome research, 2022-09, Vol.21 (9), p.2211-2223

2022

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The IQGAP1 N‑Terminus Forms Dimers, and the Dimer Interface Is Required for Binding F‑Actin and Calcium-Bound Calmodulin

Biochemistry (Easton), 2016-11, Vol.55 (46), p.6433-6444

2016

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Regulation of extracellular matrix degradation and metastatic spread by IQGAP1 through endothelin-1 receptor signalling in ovarian cancer

Matrix biology, 2019-08, Vol.81, p.17-33

2019

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Computational characterization of the chemical step in the GTP hydrolysis by Ras-GAP for the wild-type and G13V mutated Ras

Proteins, structure, function, and bioinformatics, 2015-06, Vol.83 (6), p.1046-1053

2015

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The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

Cellular signalling, 2008-03, Vol.20 (3), p.453-459

2008

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Reaction Mechanism of Guanosine Triphosphate Hydrolysis by the Vision-Related Protein Complex Arl3–RP2

The journal of physical chemistry. B, 2016-04, Vol.120 (16), p.3873-3879

2016

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Species-conserved SYNGAP1 phenotypes associated with neurodevelopmental disorders

Ras superfamily GTPase activating proteins in cancer: Potential therapeutic targets?

IQGAP1 and its binding proteins control diverse biological functions

Hydrolysis of Guanosine Triphosphate (GTP) by the Ras·GAP Protein Complex: Reaction Mechanism and Kinetic Scheme

P120-Ras GTPase activating protein (RasGAP): A multi-interacting protein in downstream signaling

DAB2IP suppresses tumor malignancy by inhibiting GRP75-driven p53 ubiquitination in colon cancer

Mutations in SYNGAP1 Cause Intellectual Disability, Autism, and a Specific Form of Epilepsy by Inducing Haploinsufficiency

IQGAP1 in cellular signaling: bridging the GAP

Large conformational changes in proteins: signaling and other functions

Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases

IQGAP1 regulation and roles in cancer

IQGAP1 regulates actin cytoskeleton organization in podocytes through interaction with nephrin

Cell cycle-dependent phosphorylation of IQGAP is involved in assembly and stability of the contractile ring in fission yeast

Modeling the Role of G12V and G13V Ras Mutations in the Ras-GAP-Catalyzed Hydrolysis Reaction of Guanosine Triphosphate

SUMOylation of IQGAP1 promotes the development of colorectal cancer

Active Rap1‐mediated inhibition of choroidal neovascularization requires interactions with IQGAP1 in choroidal endothelial cells

Real-Time Monitoring of RAS Activity Using In Vitro and In-Cell NMR Spectroscopy

Prenatal disruption of D1R-SynGAP complex causes cognitive deficits in adulthood

IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors

IQGAP1 and RNA Splicing in the Context of Head and Neck via Phosphoproteomics

The IQGAP1 N‑Terminus Forms Dimers, and the Dimer Interface Is Required for Binding F‑Actin and Calcium-Bound Calmodulin

Regulation of extracellular matrix degradation and metastatic spread by IQGAP1 through endothelin-1 receptor signalling in ovarian cancer

Computational characterization of the chemical step in the GTP hydrolysis by Ras-GAP for the wild-type and G13V mutated Ras

The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

Reaction Mechanism of Guanosine Triphosphate Hydrolysis by the Vision-Related Protein Complex Arl3–RP2

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