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Membrane transporters in drug development and as determinants of precision medicine

Nature reviews. Drug discovery, 2024-04, Vol.23 (4), p.255-280

2024

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Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)

Pharmaceutical research, 2024-03, Vol.41 (3), p.441-462

2024

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Physiologically Based Pharmacokinetic

Pharmaceutical research, 2024-03, Vol.41 (3), p.441

2024

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Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers

Pharmaceutical research, 2023-11, Vol.40 (11), p.2513-2523

2023

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Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH)

Clinical pharmacology and therapeutics, 2023-02, Vol.113 (2), p.275-297

2023

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Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium

Clinical pharmacology and therapeutics, 2022-09, Vol.112 (3), p.461-484

2022

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Clinical Relevance of Hepatic and Renal P‐gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective

Clinical pharmacology and therapeutics, 2022-09, Vol.112 (3), p.573-592

2022

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Correction to Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer’s Disease

Molecular pharmaceutics, 2021-10, Vol.18 (10), p.3928-3929

2021

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Physiologically‐Based Pharmacokinetic Model of Morphine and Morphine‐3‐Glucuronide in Nonalcoholic Steatohepatitis

Clinical pharmacology and therapeutics, 2021-03, Vol.109 (3), p.676-687

2021

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Quantitative Systems Toxicology Modeling Predicts that Reduced Biliary Efflux Contributes to Tolvaptan Hepatotoxicity

Clinical pharmacology and therapeutics, 2021-02, Vol.109 (2), p.433-442

2021

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Pregnancy-Related Hormones Increase Nifedipine Metabolism in Human Hepatocytes by Inducing CYP3A4 Expression

Journal of pharmaceutical sciences, 2021-01, Vol.110 (1), p.412-421

2021

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Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications

Clinical pharmacology and therapeutics, 2021-01, Vol.109 (1), p.55-64

2021

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Endogenous Coproporphyrin I and III are Altered in Multidrug Resistance-Associated Protein 2-Deficient (TR−) Rats

Journal of pharmaceutical sciences, 2021-01, Vol.110 (1), p.404-411

2021

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Intestinal P-gp and Putative Hepatic OATP1B Induction: ITC Perspective on Drug Development Implications

Clinical pharmacology and therapeutics, 2020-07, Vol.109 (1), p.55-64

2020

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Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside

Pharmacology & therapeutics (Oxford), 2020-07, Vol.211, p.107542-107542, Article 107542

2020

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Intestinal Permeability and Oral Absorption of Selected Drugs Are Reduced in a Mouse Model of Familial Alzheimer’s Disease

Molecular pharmaceutics, 2020-05, Vol.17 (5), p.1527-1537

2020

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Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo

Small (Weinheim an der Bergstrasse, Germany), 2020-02, Vol.16 (7), p.e1906360-n/a

2020

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Clinical Pharmacology Education – The Decade Ahead

Clinical pharmacology and therapeutics, 2020-01, Vol.107 (1), p.37-39

2020

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Increased Expression of Renal Drug Transporters in a Mouse Model of Familial Alzheimer's Disease

Journal of pharmaceutical sciences, 2019-07, Vol.108 (7), p.2484-2489

2019

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A Challenge for Clinical Pharmacologists: How Can We Measure Scientific Impact of Publications in Drug Development and in Regulatory Decision Making?

Clinical pharmacology and therapeutics, 2019-05, Vol.105 (5), p.1071-1073

2019

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Novel in Vitro Method Reveals Drugs That Inhibit Organic Solute Transporter Alpha/Beta (OSTα/β)

Molecular pharmaceutics, 2019-01, Vol.16 (1), p.238-246

2019

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Novel In Vitro Method Reveals Drugs that Inhibit Solute Transporter Alpha/Beta (OSTα/β)

Molecular pharmaceutics, 2018-12, Vol.16 (1), p.238-246

2018

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Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

Clinical pharmacology and therapeutics, 2018-11, Vol.104 (5), p.865-889

2018

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Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

Clinical pharmacology and therapeutics, 2018-11, Vol.104 (5), p.916-932

2018

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Disease‐Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium

Clinical pharmacology and therapeutics, 2018-11, Vol.104 (5), p.900-915

2018

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Membrane transporters in drug development and as determinants of precision medicine

Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)

Physiologically Based Pharmacokinetic

Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers

Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH)

Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium

Clinical Relevance of Hepatic and Renal P‐gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective

Correction to Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer’s Disease

Physiologically‐Based Pharmacokinetic Model of Morphine and Morphine‐3‐Glucuronide in Nonalcoholic Steatohepatitis

Quantitative Systems Toxicology Modeling Predicts that Reduced Biliary Efflux Contributes to Tolvaptan Hepatotoxicity

Pregnancy-Related Hormones Increase Nifedipine Metabolism in Human Hepatocytes by Inducing CYP3A4 Expression

Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications

Endogenous Coproporphyrin I and III are Altered in Multidrug Resistance-Associated Protein 2-Deficient (TR−) Rats

Intestinal P-gp and Putative Hepatic OATP1B Induction: ITC Perspective on Drug Development Implications

Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside

Intestinal Permeability and Oral Absorption of Selected Drugs Are Reduced in a Mouse Model of Familial Alzheimer’s Disease

Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo

Clinical Pharmacology Education – The Decade Ahead

Increased Expression of Renal Drug Transporters in a Mouse Model of Familial Alzheimer's Disease

A Challenge for Clinical Pharmacologists: How Can We Measure Scientific Impact of Publications in Drug Development and in Regulatory Decision Making?

Novel in Vitro Method Reveals Drugs That Inhibit Organic Solute Transporter Alpha/Beta (OSTα/β)

Novel In Vitro Method Reveals Drugs that Inhibit Solute Transporter Alpha/Beta (OSTα/β)

Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

Disease‐Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium

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