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The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions

Microvascular research, 2009-03, Vol.77 (2), p.78-86

2009

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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1522-1524

2009

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CC-5079: A Small Molecule with MKP1, Antiangiogenic, and Antitumor Activity

The Journal of surgical research, 2010-11, Vol.164 (1), p.116-125

2010

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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-a Inhibitor

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1522-1524

2009

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Antiproliferative effects of CC-8062 and CC-8075 in pancreatic cancer cells

Pancreas, 2009-01, Vol.38 (1), p.78-84

2009

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Structural Modifications of Thalidomide Produce Analogs with Enhanced Tumor Necrosis Factor Inhibitory Activity

Journal of medicinal chemistry, 1996-08, Vol.39 (17), p.3238-3240

1996

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Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production

Bioorganic & medicinal chemistry letters, 1999-06, Vol.9 (11), p.1625-1630

1999

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Potent inhibition of cytokine production from intestinal lamina propria T cells by phosphodiesterase-4 inhibitory thalidomide analogues

Journal of clinical immunology, 2001-09, Vol.21 (5), p.357-364

2001

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Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-α, IL-1β, and LPS-stimulated human PBMC in a partially IL-10-dependent manner

Cellular immunology, 2004-08, Vol.230 (2), p.81-88

2004

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Immunomodulatory Drugs (IMiDs) Increase the Production of IL-2 from Stimulated T Cells by Increasing PKC-θ Activation and Enhancing the DNA-Binding Activity of AP-1 but Not NF-κB, OCT-1, or NF-AT

Journal of interferon & cytokine research, 2005-10, Vol.25 (10), p.604-616

2005

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Carboxylic acid replacement structure-activity relationships in suosan type sweeteners. A sweet taste antagonist. 1

Journal of medicinal chemistry, 1992-05, Vol.35 (10), p.1747-1751

1992

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Thalidomide and thalidomide analogs reduce HIV type 1 replication in human macrophages in vitro

AIDS research and human retroviruses, 1997-07, Vol.13 (10), p.857-863

1997

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Immunomodulatory Drugs (IMiDs) Increase the Production of IL-2 from Stimulated T Cells by Increasing PKC-[theta] Activation and Enhancing the DNA-Binding Activity of AP-1 but Not NF-[kappa]B, OCT-1, or NF-AT

Journal of interferon & cytokine research, 2005-10, Vol.25 (10), p.604

2005

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Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT

Journal of interferon & cytokine research, 2005-10, Vol.25 (10), p.604

2005

Volltextzugriff (PDF)

Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha, IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner

Cellular immunology, 2004-08, Vol.230 (2), p.81-88

2004

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Thalidomide analogs, but not thalidomide itself, are potent inhMitors of lamina propria mononuclear cell (LPMC) TNF-A and IFN-कproduction in response to T cell stimuli

Gastroenterology (New York, N.Y. 1943), 2000-04, Vol.118 (4), p.A586-A586

2000

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Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1522-1524

2009

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TNF-α inhibitors and rheumatoid arthritis

Expert opinion on therapeutic patents, 1998-05, Vol.8 (5), p.531-544

1998

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TNF- inhibitors and rheumatoid arthritis

Expert opinion on therapeutic patents, 1998-05, Vol.8 (5), p.531-544

1998

Volltextzugriff (PDF)

A regiospecific and highly stereoselective approach to the synthesis of linearly fused tricyclopentanoids. Intramolecular diyl trapping reactions

Journal of the American Chemical Society, 1979-11, Vol.101 (23), p.7129-7130

1979

Volltextzugriff (PDF)

α-Fluoro-Substituted Thalidomide Analogues

ChemInform, 2004-01, Vol.35 (3), p.no-no

2004

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ChemInform Abstract: Amino-Substituted Thalidomide Analogues: Potent Inhibitors of TNF-α Production

ChemInform, 1999-09, Vol.30 (37), p.no-no

1999

Volltextzugriff (PDF)

New insights into the pathogenesis and nonsurgical management of Graves orbitopathy

Nature reviews. Endocrinology, 2020-02, Vol.16 (2), p.104

2020

Volltextzugriff (PDF)

Identification of common genetic risk variants for autism spectrum disorder

Nature genetics, 2019-03, Vol.51 (3), p.431-444

2019

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The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

CC-5079: A Small Molecule with MKP1, Antiangiogenic, and Antitumor Activity

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-a Inhibitor

Antiproliferative effects of CC-8062 and CC-8075 in pancreatic cancer cells

Structural Modifications of Thalidomide Produce Analogs with Enhanced Tumor Necrosis Factor Inhibitory Activity

Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production

Potent inhibition of cytokine production from intestinal lamina propria T cells by phosphodiesterase-4 inhibitory thalidomide analogues

Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-α, IL-1β, and LPS-stimulated human PBMC in a partially IL-10-dependent manner

Immunomodulatory Drugs (IMiDs) Increase the Production of IL-2 from Stimulated T Cells by Increasing PKC-θ Activation and Enhancing the DNA-Binding Activity of AP-1 but Not NF-κB, OCT-1, or NF-AT

Carboxylic acid replacement structure-activity relationships in suosan type sweeteners. A sweet taste antagonist. 1

Thalidomide and thalidomide analogs reduce HIV type 1 replication in human macrophages in vitro

Immunomodulatory Drugs (IMiDs) Increase the Production of IL-2 from Stimulated T Cells by Increasing PKC-[theta] Activation and Enhancing the DNA-Binding Activity of AP-1 but Not NF-[kappa]B, OCT-1, or NF-AT

Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT

Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha, IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner

Thalidomide analogs, but not thalidomide itself, are potent inhMitors of lamina propria mononuclear cell (LPMC) TNF-A and IFN-कproduction in response to T cell stimuli

Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor

TNF-α inhibitors and rheumatoid arthritis

TNF- inhibitors and rheumatoid arthritis

A regiospecific and highly stereoselective approach to the synthesis of linearly fused tricyclopentanoids. Intramolecular diyl trapping reactions

α-Fluoro-Substituted Thalidomide Analogues

ChemInform Abstract: Amino-Substituted Thalidomide Analogues: Potent Inhibitors of TNF-α Production

Vegetation demographics in Earth System Models: A review of progress and priorities

New insights into the pathogenesis and nonsurgical management of Graves orbitopathy

Identification of common genetic risk variants for autism spectrum disorder

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