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Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target

Archives of toxicology, 2017-07, Vol.91 (7), p.2497-2513

2017

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Metformin-induced anticancer activities: recent insights

Biological chemistry, 2018-03, Vol.399 (4), p.321-335

2018

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Sp transcription factor family and its role in cancer

European journal of cancer (1990), 2005-11, Vol.41 (16), p.2438-2448

2005

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Novel diindolylmethane derivatives based NLC formulations to improve the oral bioavailability and anticancer effects in triple negative breast cancer

European journal of pharmaceutics and biopharmaceutics, 2016-11, Vol.108, p.168-179

2016

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Flavonoids: structure–function and mechanisms of action and opportunities for drug development

한국독성학회지, 2021, 37(2), , pp.147-162

2021

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Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs

Anti-cancer agents in medicinal chemistry, 2012-12, Vol.12 (10), p.1211-1220

2012

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Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK)

Cellular signalling, 2017-12, Vol.40, p.172-182

2017

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Omeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway

Chemical research in toxicology, 2015-05, Vol.28 (5), p.907-918

2015

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Clinical correlates of environmental endocrine disruptors

Trends in endocrinology and metabolism, 2005-05, Vol.16 (4), p.139-144

Safe, Stephen

2005

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The aryl hydrocarbon receptor (AhR) as a drug target for cancer chemotherapy

Current opinion in toxicology, 2017-02, Vol.2, p.24-29

2017

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Pharmacological activation of Nr4a rescues age-associated memory decline

Neurobiology of aging, 2020-01, Vol.85, p.140-144

2020

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Toxicological and pathophysiological roles of reactive oxygen and nitrogen species

Toxicology (Amsterdam), 2010-10, Vol.276 (2), p.85-94

2010

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Structure‐dependent activation of gene expression by bis‐indole and quinoline‐derived activators of nuclear receptor 4A2

Chemical biology & drug design, 2019-10, Vol.94 (4), p.1711-1720

2019

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Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (8), p.2633-2639

2008

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Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure–Activity Relationships

Chemical research in toxicology, 2019-11, Vol.32 (11), p.2353-2364

2019

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Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth

Experimental cell research, 2010-08, Vol.316 (13), p.2174-2188

2010

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The Bioactive Compounds [alpha]-Chaconine and Gallic Acid in Potato Extracts Decrease Survival and Induce Apoptosis in LNCaP and PC3 Prostate Cancer Cells

Nutrition and cancer, 2010-07, Vol.62 (5), p.601

2010

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Natural Products as Mechanism-based Anticancer Agents: Sp Transcription Factors as Targets

Phytotherapy research, 2016-11, Vol.30 (11), p.1723-1732

2016

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The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis

Molecular nutrition & food research, 2013-09, Vol.57 (9), p.1638-1648

2013

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Absorption and Biological Activity of Phytochemical-Rich Extracts from Acai (Euterpe oleracea Mart.) Pulp and Oil in Vitro

Journal of agricultural and food chemistry, 2008-05, Vol.56 (10), p.3593-3600

2008

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Polychlorinated Biphenyls (PCBs): Environmental Impact, Biochemical and Toxic Responses, and Implications for Risk Assessment

Critical reviews in toxicology, 1994, Vol.24 (2), p.87-149

Safe, Stephen H.

1994

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A novel diindolylmethane analog, 1,1-bis(3’-indolyl)-1-(p-chlorophenyl) methane, inhibits the tumor necrosis factor-induced inflammatory response in primary murine synovial fibroblasts through a Nurr1-dependent mechanism

Molecular immunology, 2018-09, Vol.101, p.46-54

2018

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Pharmacologic Doses of Ascorbic Acid Repress Specificity Protein (Sp) Transcription Factors and Sp-Regulated Genes in Colon Cancer Cells

Nutrition and cancer, 2011-10, Vol.63 (7), p.1133-1142

2011

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2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice

Toxicology and applied pharmacology, 2016-08, Vol.305, p.242-249

2016

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Excited about Receptors

Receptors, 2022-05, Vol.1 (1), p.1-2

Safe, Stephen

2022

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Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target

Metformin-induced anticancer activities: recent insights

Sp transcription factor family and its role in cancer

Novel diindolylmethane derivatives based NLC formulations to improve the oral bioavailability and anticancer effects in triple negative breast cancer

Flavonoids: structure–function and mechanisms of action and opportunities for drug development

Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs

Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK)

Omeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway

Clinical correlates of environmental endocrine disruptors

The aryl hydrocarbon receptor (AhR) as a drug target for cancer chemotherapy

Pharmacological activation of Nr4a rescues age-associated memory decline

Toxicological and pathophysiological roles of reactive oxygen and nitrogen species

Structure‐dependent activation of gene expression by bis‐indole and quinoline‐derived activators of nuclear receptor 4A2

Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives

Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure–Activity Relationships

Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth

The Bioactive Compounds [alpha]-Chaconine and Gallic Acid in Potato Extracts Decrease Survival and Induce Apoptosis in LNCaP and PC3 Prostate Cancer Cells

Natural Products as Mechanism-based Anticancer Agents: Sp Transcription Factors as Targets

The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis

Absorption and Biological Activity of Phytochemical-Rich Extracts from Acai (Euterpe oleracea Mart.) Pulp and Oil in Vitro

Polychlorinated Biphenyls (PCBs): Environmental Impact, Biochemical and Toxic Responses, and Implications for Risk Assessment

A novel diindolylmethane analog, 1,1-bis(3’-indolyl)-1-(p-chlorophenyl) methane, inhibits the tumor necrosis factor-induced inflammatory response in primary murine synovial fibroblasts through a Nurr1-dependent mechanism

Pharmacologic Doses of Ascorbic Acid Repress Specificity Protein (Sp) Transcription Factors and Sp-Regulated Genes in Colon Cancer Cells

2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice

Excited about Receptors

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