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Harnessing PROTACs to combat H5N1 influenza: A new frontier in viral destruction

Journal of medical virology, 2024-09, Vol.96 (9), p.e29926-n/a

2024

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Between Theory and Practice: Computational/Experimental Integrated Approaches to Understand the Solubility and Lipophilicity of PROTACs

Journal of medicinal chemistry, 2024-09, Vol.67 (18), p.16355-16380

2024

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Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis

Journal of medicinal chemistry, 2024-09, Vol.67 (18), p.16712-16736

2024

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CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals

Molecular neurodegeneration, 2024-11, Vol.19 (1), Article 82

2024

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Calpain-5 regulates muscle-specific protein expression and nuclear positioning during myoblast differentiation

The Journal of biological chemistry, 2024-09, Vol.300 (11), p.107842, Article 107842

2024

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Screen for temperature-sensitive mutants of non-essential yeast genes

Methods in enzymology, 2024, Vol.707, p.611-634

2024

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BRD4-specific PROTAC inhibits basal-like breast cancer partially through downregulating KLF5 expression

Oncogene, 2024-09, Vol.43 (39), p.2914-2926

2024

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Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition

Cell reports. Medicine, 2024-10, Vol.5 (10), p.101752, Article 101752

2024

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High resolution analysis of proteolytic substrate processing

The Journal of biological chemistry, 2024-11, Vol.300 (11), p.107812, Article 107812

2024

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Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog

The Journal of biological chemistry, 2024-10, Vol.300 (10), p.107763, Article 107763

2024

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N-degron pathways

Proceedings of the National Academy of Sciences - PNAS, 2024-09, Vol.121 (39), p.e2408697121

Varshavsky, Alexander

2024

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KRAS takes the road to destruction

Science (American Association for the Advancement of Science), 2024-09, Vol.385 (6715), p.1274-1275

2024

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Light‐Triggered PROTAC Nanoassemblies for Photodynamic IDO Proteolysis in Cancer Immunotherapy (Adv. Mater. 38/2024)

Advanced materials (Weinheim), 2024-09, Vol.36 (38), p.n/a

2024

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Therapeutic potential of archaeal unfoldase PAN.sup.et and the gateless T20S proteasome in P23H rhodopsin retinitis pigmentosa mice

PloS one, 2024-10, Vol.19 (10), p.e0308058

2024

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Proteolytic degradation of seed proteins of vetch species (Vicia L. subgenus Vicia) of section Peregrinae Kupicha during SDS-electrophoresis and its prevention

Biotehnologiâ i selekciâ rastenij (Online), 2024-10, Vol.7 (3), p.5-18

2024

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EVALUATION OF PROTEOLYTIC ACTIVITY IN EXPERIMENTAL PERITONITIS WITH SEROGUARD® TREATMENT

Paëmi Sino, 2024-09, Vol.26 (3), p.417-426

2024

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ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation

Gut, 2024-10, p.gutjnl-2024-333213

2024

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Delineation of the substrate recognition domain of MARCHF6 E3 ubiquitin ligase in the Ac/N-degron pathway and its regulatory role in ferroptosis

The Journal of biological chemistry, 2024-10, Vol.300 (10), p.107731, Article 107731

2024

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Microbial hoolIgAn dismantles gut defenses

Science (American Association for the Advancement of Science), 2024-09, Vol.385 (6716), p.1418-1420

Slack, Emma

2024

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Fibrosis uncovered: ADAMTS12 cuts to the core of extracellular matrix drama

The Journal of clinical investigation, 2024-09, Vol.134 (18), p.1-3

2024

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PROTAC-mediated vimentin degradation promotes terminal erythroid differentiation of pluripotent stem cells

Stem cell research & therapy, 2024-09, Vol.15 (1), p.310-15, Article 310

2024

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Cryo-EM structure of a lysozyme-derived amyloid fibril from hereditary amyloidosis

Nature communications, 2024-11, Vol.15 (1), p.9648-9, Article 9648

2024

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Metagenomic Analysis Reveals Large‐Scale Disruptions of the Gut Microbiome in Parkinson's Disease

Movement disorders, 2024-10, Vol.39 (10), p.1740-1751

2024

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Serratiopeptidase exhibits antibiofilm activity through the proteolytic function of N-terminal domain and versatile function of the C-terminal domain

Biochimica et biophysica acta. Proteins and proteomics, 2025-01, Vol.1873 (1), p.141046, Article 141046

2025

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Accounting for Digestion Enzyme Bias in Casanovo

Journal of proteome research, 2024-10, Vol.23 (10), p.4761-4769

2024

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Harnessing PROTACs to combat H5N1 influenza: A new frontier in viral destruction

Between Theory and Practice: Computational/Experimental Integrated Approaches to Understand the Solubility and Lipophilicity of PROTACs

Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis

CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals

Calpain-5 regulates muscle-specific protein expression and nuclear positioning during myoblast differentiation

Screen for temperature-sensitive mutants of non-essential yeast genes

BRD4-specific PROTAC inhibits basal-like breast cancer partially through downregulating KLF5 expression

Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition

High resolution analysis of proteolytic substrate processing

Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog

N-degron pathways

KRAS takes the road to destruction

Light‐Triggered PROTAC Nanoassemblies for Photodynamic IDO Proteolysis in Cancer Immunotherapy (Adv. Mater. 38/2024)

Therapeutic potential of archaeal unfoldase PAN.sup.et and the gateless T20S proteasome in P23H rhodopsin retinitis pigmentosa mice

Proteolytic degradation of seed proteins of vetch species (Vicia L. subgenus Vicia) of section Peregrinae Kupicha during SDS-electrophoresis and its prevention

EVALUATION OF PROTEOLYTIC ACTIVITY IN EXPERIMENTAL PERITONITIS WITH SEROGUARD® TREATMENT

ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation

Delineation of the substrate recognition domain of MARCHF6 E3 ubiquitin ligase in the Ac/N-degron pathway and its regulatory role in ferroptosis

Microbial hoolIgAn dismantles gut defenses

Fibrosis uncovered: ADAMTS12 cuts to the core of extracellular matrix drama

PROTAC-mediated vimentin degradation promotes terminal erythroid differentiation of pluripotent stem cells

Cryo-EM structure of a lysozyme-derived amyloid fibril from hereditary amyloidosis

Metagenomic Analysis Reveals Large‐Scale Disruptions of the Gut Microbiome in Parkinson's Disease

Serratiopeptidase exhibits antibiofilm activity through the proteolytic function of N-terminal domain and versatile function of the C-terminal domain

Accounting for Digestion Enzyme Bias in Casanovo

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