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Clinical trials in older patients with cancer – typical challenges, possible solutions, and a paradigm of study design in breast cancer

Acta oncologica, 2024-06, Vol.63 (1), p.441-447

2024

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Active conventional treatment and three different biological treatments in early rheumatoid arthritis: phase IV investigator initiated, randomised, observer blinded clinical trial

BMJ (Online), 2020-12, Vol.371, p.m4328

2020

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Laparoscopic lavage for Hinchey III perforated diverticulitis: factors for treatment failure in two randomized clinical trials

British journal of surgery, 2023-06, Vol.110 (7), p.846-851

2023

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Implementation of a centralized pharmacovigilance system in academic pan‐European clinical trials: Experience from EU‐Response and conect4children consortia

British journal of clinical pharmacology, 2023-04, Vol.89 (4), p.1318-1328

2023

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Adverse Effects and Safety in Glaucoma Patients: Agreement on Clinical Trial Outcomes for Reports on Eye Drops (ASGARD)—A Delphi Consensus Statement

American journal of ophthalmology, 2022-09, Vol.241, p.190-197

2022

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Anxiety, Depression, and Insomnia Among Adults With Opioid Dependence Treated With Extended-Release Naltrexone vs Buprenorphine-Naloxone: A Randomized Clinical Trial and Follow-up Study

JAMA psychiatry (Chicago, Ill.), 2019-02, Vol.76 (2), p.127

2019

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Improved patient participation through advance care planning in nursing homes—A cluster randomized clinical trial

Patient education and counseling, 2019-12, Vol.102 (12), p.2183-2191

2019

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Clinical trial: An open‐label, randomised trial of different re‐start strategies after treatment withdrawal in HBeAg negative chronic hepatitis B

Alimentary pharmacology & therapeutics, 2024-08, Vol.60 (4), p.434-445

2024

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Dual or single antiplatelet therapy after coronary surgery for acute coronary syndrome (TACSI trial): Rationale and design of an investigator-initiated, prospective, multinational, registry-based randomized clinical trial

The American heart journal, 2023-05, Vol.259, p.1-8

2023

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Potassium infusion increases the likelihood of conversion of recent-onset atrial fibrillation—A single-blinded, randomized clinical trial

The American heart journal, 2020-03, Vol.221, p.114-124

2020

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Availability of post-trial access in clinical trials: a review of clinical trial protocols submitted to the research ethics board of the University of the Philippines Manila

Current medical research and opinion, 2019-11, Vol.35 (11), p.1849-1855

2019

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TheraPearl Eye Mask and Blephasteam for the treatment of meibomian gland dysfunction: a randomized, comparative clinical trial

Scientific reports, 2021-11, Vol.11 (1), p.22386-22386, Article 22386

2021

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The age of randomized clinical trials: three important aspects of randomized clinical trials in cardiovascular pharmacotherapy with examples from lipid and diabetes trials

European heart journal. Cardiovascular pharmacotherapy, 2020-04, Vol.6 (2), p.97-103

2020

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The effects of a psycho‐educational intervention to improve pain management after day surgery: A randomised clinical trial

Journal of clinical nursing, 2021-04, Vol.30 (7-8), p.1132-1143

2021

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Accuracy of breast MRI in patients receiving neoadjuvant endocrine therapy: comprehensive imaging analysis and correlation with clinical and pathological assessments

Breast cancer research and treatment, 2020-11, Vol.184 (2), p.407-420

2020

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Subgroup analyses in randomized clinical trials: value and limitations. Review #3 on important aspects of randomized clinical trials in cardiovascular pharmacotherapy

European heart journal. Cardiovascular pharmacotherapy, 2022-05, Vol.8 (3), p.302-310

2022

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Non‐surgical treatment of mild to moderate peri‐implantitis using an oscillating chitosan brush or a titanium curette—A randomized multicentre controlled clinical trial

Clinical oral implants research, 2022-12, Vol.33 (12), p.1254-1264

2022

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Health‐related quality of life in adults with drug‐resistant focal epilepsy treated with modified Atkins diet in a randomized clinical trial

Epilepsia (Copenhagen), 2023-05, Vol.64 (5), p.e69-e74

2023

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Comparison of commercially available 0.2% chlorhexidine mouthwash with and without anti‐discoloration system: A blinded, crossover clinical trial

Journal of clinical periodontology, 2020-12, Vol.47 (12), p.1522-1527

2020

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Longitudinal corneal endothelial cell loss after corrective surgery for late in-the-bag IOL dislocation: randomized clinical trial

Journal of cataract and refractive surgery, 2020-07, Vol.46 (7), p.1030-1036

2020

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Stability, survival, and patient satisfaction with CAD/CAM versus conventional multistranded fixed retainers in orthodontic patients: a 6-month follow-up of a two-centre randomized controlled clinical trial

European journal of orthodontics, 2023-02, Vol.45 (1), p.58-67

2023

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Selenium and Coenzyme Q10 Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality—Sub-Study of a Randomized Clinical Trial

Nutrients, 2022-08, Vol.14 (16), p.3346

2022

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Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets

The journal of pathology. Clinical research, 2023-11, Vol.9 (6), p.449-463

2023

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Risk of Relapse Among Opioid‐Dependent Patients Treated With Extended‐Release Naltrexone or Buprenorphine‐Naloxone: A Randomized Clinical Trial

The American journal on addictions, 2021-09, Vol.30 (5), p.453-460

2021

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Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial

PloS one, 2017-05, Vol.12 (5), p.e0176527-e0176527

2017

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Clinical trials in older patients with cancer – typical challenges, possible solutions, and a paradigm of study design in breast cancer

Active conventional treatment and three different biological treatments in early rheumatoid arthritis: phase IV investigator initiated, randomised, observer blinded clinical trial

Laparoscopic lavage for Hinchey III perforated diverticulitis: factors for treatment failure in two randomized clinical trials

Implementation of a centralized pharmacovigilance system in academic pan‐European clinical trials: Experience from EU‐Response and conect4children consortia

Adverse Effects and Safety in Glaucoma Patients: Agreement on Clinical Trial Outcomes for Reports on Eye Drops (ASGARD)—A Delphi Consensus Statement

Anxiety, Depression, and Insomnia Among Adults With Opioid Dependence Treated With Extended-Release Naltrexone vs Buprenorphine-Naloxone: A Randomized Clinical Trial and Follow-up Study

Improved patient participation through advance care planning in nursing homes—A cluster randomized clinical trial

Clinical trial: An open‐label, randomised trial of different re‐start strategies after treatment withdrawal in HBeAg negative chronic hepatitis B

Dual or single antiplatelet therapy after coronary surgery for acute coronary syndrome (TACSI trial): Rationale and design of an investigator-initiated, prospective, multinational, registry-based randomized clinical trial

Potassium infusion increases the likelihood of conversion of recent-onset atrial fibrillation—A single-blinded, randomized clinical trial

Availability of post-trial access in clinical trials: a review of clinical trial protocols submitted to the research ethics board of the University of the Philippines Manila

TheraPearl Eye Mask and Blephasteam for the treatment of meibomian gland dysfunction: a randomized, comparative clinical trial

The age of randomized clinical trials: three important aspects of randomized clinical trials in cardiovascular pharmacotherapy with examples from lipid and diabetes trials

The effects of a psycho‐educational intervention to improve pain management after day surgery: A randomised clinical trial

Accuracy of breast MRI in patients receiving neoadjuvant endocrine therapy: comprehensive imaging analysis and correlation with clinical and pathological assessments

Subgroup analyses in randomized clinical trials: value and limitations. Review #3 on important aspects of randomized clinical trials in cardiovascular pharmacotherapy

Non‐surgical treatment of mild to moderate peri‐implantitis using an oscillating chitosan brush or a titanium curette—A randomized multicentre controlled clinical trial

Health‐related quality of life in adults with drug‐resistant focal epilepsy treated with modified Atkins diet in a randomized clinical trial

Comparison of commercially available 0.2% chlorhexidine mouthwash with and without anti‐discoloration system: A blinded, crossover clinical trial

Longitudinal corneal endothelial cell loss after corrective surgery for late in-the-bag IOL dislocation: randomized clinical trial

Stability, survival, and patient satisfaction with CAD/CAM versus conventional multistranded fixed retainers in orthodontic patients: a 6-month follow-up of a two-centre randomized controlled clinical trial

Selenium and Coenzyme Q10 Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality—Sub-Study of a Randomized Clinical Trial

Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets

Risk of Relapse Among Opioid‐Dependent Patients Treated With Extended‐Release Naltrexone or Buprenorphine‐Naloxone: A Randomized Clinical Trial

Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial

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