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Role of GxxxG Motifs in Transmembrane Domain Interactions

Biochemistry (Easton), 2015-08, Vol.54 (33), p.5125-5135

2015

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Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides

The Journal of biological chemistry, 2021-01, Vol.296, p.100393, Article 100393

2021

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Abstract 1344 Role of GXXXG Dimerization Motif and Lipid-Protein Interactions in the Functional Modulation of Glutamate Carboxypeptidase II

The Journal of biological chemistry, 2024-03, Vol.300 (3), p.106873, Article 106873

2024

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Differential pairing of transmembrane domain GxxxG dimerization motifs defines two HLA-DR MHC class II conformers

The Journal of biological chemistry, 2023-07, Vol.299 (7), p.104869, Article 104869

2023

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A frequent, GxxxG-mediated, transmembrane association motif is optimized for the formation of interhelical Cα–H hydrogen bonds

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (10), p.3661-3661

2014

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Effects of Gly Residue and Cholesterol on the GXXXG‐Mediated Parallel Association of Transmembrane Helices: A Single‐Pair FRET Study

Chembiochem : a European journal of chemical biology, 2022-12, Vol.23 (23), p.e202200160-n/a

2022

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Conserved GxxxG and WN motifs of MIC13 are essential for bridging two MICOS subcomplexes

Biochimica et biophysica acta. Biomembranes, 2021-12, Vol.1863 (12), p.183683-183683, Article 183683

2021

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GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42

The EMBO journal, 2007-03, Vol.26 (6), p.1702-1712

2007

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Combination of Cα–H Hydrogen Bonds and van der Waals Packing Modulates the Stability of GxxxG-Mediated Dimers in Membranes

Journal of the American Chemical Society, 2017-11, Vol.139 (44), p.15774-15783

2017

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Construction of Self-Assembling Lipopeptide-Based Benign Nanovesicles to Prevent Amyloid Fibril Formation and Reduce Cytotoxicity of GxxxGxxxGxxxG Motif

Bioconjugate chemistry, 2022-06, Vol.33 (6), p.1201-1209

2022

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A Transmembrane Domain and GxxxG Motifs within L2 Are Essential for Papillomavirus Infection

Journal of Virology, 2013-01, Vol.87 (1), p.464-473

2013

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O19 Differential pairing of transmembrane domain GxxxG dimerization motifs generates two HLA-DR conformers defined by selective binding by the mAb Tü36

Human immunology, 2023-09, Vol.84, p.34-34

2023

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GxxxG Motif Stabilize Ion-Channel like Pores through C α -H···O Interaction in Aβ (1-40)

International journal of molecular sciences, 2023-01, Vol.24 (3), p.2192

2023

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Self‐Assembly and Neurotoxicity of β‐Amyloid (21–40) Peptide Fragment: The Regulatory Role of GxxxG Motifs

ChemMedChem, 2020-02, Vol.15 (3), p.293-301

2020

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GXXXG‐Mediated Parallel and Antiparallel Dimerization of Transmembrane Helices and Its Inhibition by Cholesterol: Single‐Pair FRET and 2D IR Studies

Angewandte Chemie International Edition, 2017-02, Vol.56 (7), p.1756-1759

International ed. in English, 2017

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A conserved GXXXG motif in the transmembrane domain of CLIC proteins is essential for their cholesterol-dependant membrane interaction

Biochimica et biophysica acta. General subjects, 2019-08, Vol.1863 (8), p.1243-1253

2019

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A GXXXA Motif in the Transmembrane Domain of the Ebola Virus Glycoprotein Is Required for Tetherin Antagonism

Journal of virology, 2018-07, Vol.92 (13)

2018

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Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs

Current opinion in structural biology, 2004-08, Vol.14 (4), p.465-479

2004

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Sterical Recognition at Helix–Helix Interface of Leu-Aib-Based Polypeptides with and without a GxxxG-Motif

Langmuir, 2019-06, Vol.35 (22), p.7249-7254

2019

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Interplay between Amino Acid Sequences and Lipid Compositions in the GXXXG-Mediated Parallel Self-Association of Transmembrane Helices as Revealed by Single-pair Fret

Biophysical journal, 2020-02, Vol.118 (3), p.368a-368a

2020

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SOBIR1 requires the GxxxG dimerization motif in its transmembrane domain to form constitutive complexes with receptor‐like proteins

Molecular plant pathology, 2016-01, Vol.17 (1), p.96-107

2016

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Identification of GXXXXG motif in Chrysophsin-1 and its implication in the design of analogs with cell-selective antimicrobial and anti-endotoxin activities

Scientific reports, 2017-06, Vol.7 (1), p.3384-16, Article 3384

2017

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Delineating the Role of GxxxG Motif in Amyloidogenesis: A New Perspective in Targeting Amyloid-Beta Mediated AD Pathogenesis

ACS bio & med chem au, 2024-02, Vol.4 (1), p.4-19

2024

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Alanine substitutions in the GXXXG motif alter C99 cleavage by γ‐secretase but not its dimerization

Journal of neurochemistry, 2017-03, Vol.140 (6), p.955-962

2017

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GxxxG motifs hold the TIM23 complex together

The FEBS journal, 2015-06, Vol.282 (11), p.2178-2186

2015

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Role of GxxxG Motifs in Transmembrane Domain Interactions

Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides

Abstract 1344 Role of GXXXG Dimerization Motif and Lipid-Protein Interactions in the Functional Modulation of Glutamate Carboxypeptidase II

Differential pairing of transmembrane domain GxxxG dimerization motifs defines two HLA-DR MHC class II conformers

A frequent, GxxxG-mediated, transmembrane association motif is optimized for the formation of interhelical Cα–H hydrogen bonds

Effects of Gly Residue and Cholesterol on the GXXXG‐Mediated Parallel Association of Transmembrane Helices: A Single‐Pair FRET Study

Conserved GxxxG and WN motifs of MIC13 are essential for bridging two MICOS subcomplexes

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42

Combination of Cα–H Hydrogen Bonds and van der Waals Packing Modulates the Stability of GxxxG-Mediated Dimers in Membranes

Construction of Self-Assembling Lipopeptide-Based Benign Nanovesicles to Prevent Amyloid Fibril Formation and Reduce Cytotoxicity of GxxxGxxxGxxxG Motif

A Transmembrane Domain and GxxxG Motifs within L2 Are Essential for Papillomavirus Infection

O19 Differential pairing of transmembrane domain GxxxG dimerization motifs generates two HLA-DR conformers defined by selective binding by the mAb Tü36

GxxxG Motif Stabilize Ion-Channel like Pores through C α -H···O Interaction in Aβ (1-40)

Self‐Assembly and Neurotoxicity of β‐Amyloid (21–40) Peptide Fragment: The Regulatory Role of GxxxG Motifs

GXXXG‐Mediated Parallel and Antiparallel Dimerization of Transmembrane Helices and Its Inhibition by Cholesterol: Single‐Pair FRET and 2D IR Studies

A conserved GXXXG motif in the transmembrane domain of CLIC proteins is essential for their cholesterol-dependant membrane interaction

A GXXXA Motif in the Transmembrane Domain of the Ebola Virus Glycoprotein Is Required for Tetherin Antagonism

Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs

Sterical Recognition at Helix–Helix Interface of Leu-Aib-Based Polypeptides with and without a GxxxG-Motif

Interplay between Amino Acid Sequences and Lipid Compositions in the GXXXG-Mediated Parallel Self-Association of Transmembrane Helices as Revealed by Single-pair Fret

SOBIR1 requires the GxxxG dimerization motif in its transmembrane domain to form constitutive complexes with receptor‐like proteins

Identification of GXXXXG motif in Chrysophsin-1 and its implication in the design of analogs with cell-selective antimicrobial and anti-endotoxin activities

Delineating the Role of GxxxG Motif in Amyloidogenesis: A New Perspective in Targeting Amyloid-Beta Mediated AD Pathogenesis

Alanine substitutions in the GXXXG motif alter C99 cleavage by γ‐secretase but not its dimerization

GxxxG motifs hold the TIM23 complex together

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