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Astrocyte-Derived Exosomal microRNA miR-200a-3p Prevents MPP+-Induced Apoptotic Cell Death Through Down-Regulation of MKK4

Neurochemical research, 2020-05, Vol.45 (5), p.1020-1033

2020

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AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade

Plant physiology (Bethesda), 2017-02, Vol.173 (2), p.1391-1408

2017

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MKK4-MPK3-WRKY17-mediated salicylic acid degradation increases susceptibility to Glomerella leaf spot in apple

Plant physiology (Bethesda), 2021-06, Vol.186 (2), p.1202-1219

2021

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Phytophthora infestans RXLR effector PITG20303 targets a potato MKK1 protein to suppress plant immunity

The New phytologist, 2021-01, Vol.229 (1), p.501-515

2021

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Mitogen-Activated Protein Kinase Cascade MKK7-MPK6 Plays Important Roles in Plant Development and Regulates Shoot Branching by Phosphorylating PIN1 in Arabidopsis

PLoS biology, 2016-09, Vol.14 (9), p.e1002550-e1002550

2016

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Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NF-κB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways

Journal of Immunology Research, 2021, Vol.2021, p.9944880-11

2021

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Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation

Science (American Association for the Advancement of Science), 2023-09, Vol.381 (6663), p.1217-1225

2023

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The retrograde signaling regulator ANAC017 recruits the MKK9-MPK3/6, ethylene, and auxin signaling pathways to balance mitochondrial dysfunction with growth

The Plant cell, 2022-08, Vol.34 (9), p.3460-3481

2022

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Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor

Cell chemical biology, 2019-01, Vol.26 (1), p.98-108.e5

2019

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Maternal control of embryogenesis by MPK6 and its upstream MKK4/MKK5 in Arabidopsis

The Plant journal : for cell and molecular biology, 2017-12, Vol.92 (6), p.1005-1019

2017

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The MEKK1-MKK1/MKK2-MPK4 Kinase Cascade Negatively Regulates Immunity Mediated by a Mitogen-Activated Protein Kinase Kinase Kinase in Arabidopsis

The Plant cell, 2012-05, Vol.24 (5), p.2225-2236

2012

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MKK6 controls T3-mediated browning of white adipose tissue

Nature communications, 2017-10, Vol.8 (1), p.856-14, Article 856

2017

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The bacterial effector HopZ1a acetylates MKK7 to suppress plant immunity

The New phytologist, 2021-08, Vol.231 (3), p.1138-1156

2021

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βC1 protein encoded in geminivirus satellite concertedly targets MKK2 and MPK4 to counter host defense

PLoS pathogens, 2019-04, Vol.15 (4), p.e1007728-e1007728

2019

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MKK4/MKK5-MPK1/MPK2 cascade mediates SA-activated leaf senescence via phosphorylation of NPR1 in Arabidopsis

Plant molecular biology, 2020-03, Vol.102 (4-5), p.463-475

2020

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EDR1 physically interacts with MKK4/MKK5 and negatively regulates a MAP kinase cascade to modulate plant innate immunity

PLoS genetics, 2014-05, Vol.10 (5), p.e1004389-e1004389

2014

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Mefunidone ameliorates acute liver failure in mice by inhibiting MKK4-JNK pathway

Biochemical pharmacology, 2024-07, Vol.225, p.116267, Article 116267

2024

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The YDA-MKK4/MKK5-MPK3/MPK6 Cascade Functions Downstream of the RGF1-RGI Ligand–Receptor Pair in Regulating Mitotic Activity in Root Apical Meristem

Molecular plant, 2020-11, Vol.13 (11), p.1608-1623

2020

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(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD

Cell death and differentiation, 2012-10, Vol.19 (10), p.1623-1633

2012

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A novel methuosis inducer DZ-514 possesses antitumor activity via activation of ROS-MKK4-p38 axis in triple negative breast cancer

Cancer letters, 2023-02, Vol.555, p.216049, Article 216049

2023

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Histone deacetylase 6 promotes growth of glioblastoma through the MKK7/JNK/c‐Jun signaling pathway

Journal of neurochemistry, 2020-01, Vol.152 (2), p.221-234

2020

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MicroRNA-145 attenuates TNF-α-driven cartilage matrix degradation in osteoarthritis via direct suppression of MKK4

Cell death & disease, 2017-10, Vol.8 (10), p.e3140-e3140

2017

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Phosphatidic acid promotes the activation and plasma membrane localization of MKK7 and MKK9 in response to salt stress

Plant science (Limerick), 2019-10, Vol.287, p.110190-110190, Article 110190

2019

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The Raf‐like MAPKKKs STY8, STY17, and STY46 negatively regulate Botrytis cinerea resistance by limiting MKK7 protein accumulation in Arabidopsis

The Plant journal : for cell and molecular biology, 2024-03, Vol.117 (5), p.1503-1516

2024

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First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Astrocyte-Derived Exosomal microRNA miR-200a-3p Prevents MPP+-Induced Apoptotic Cell Death Through Down-Regulation of MKK4

AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade

MKK4-MPK3-WRKY17-mediated salicylic acid degradation increases susceptibility to Glomerella leaf spot in apple

Phytophthora infestans RXLR effector PITG20303 targets a potato MKK1 protein to suppress plant immunity

Mitogen-Activated Protein Kinase Cascade MKK7-MPK6 Plays Important Roles in Plant Development and Regulates Shoot Branching by Phosphorylating PIN1 in Arabidopsis

Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NF-κB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways

Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation

The retrograde signaling regulator ANAC017 recruits the MKK9-MPK3/6, ethylene, and auxin signaling pathways to balance mitochondrial dysfunction with growth

Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor

Maternal control of embryogenesis by MPK6 and its upstream MKK4/MKK5 in Arabidopsis

The MEKK1-MKK1/MKK2-MPK4 Kinase Cascade Negatively Regulates Immunity Mediated by a Mitogen-Activated Protein Kinase Kinase Kinase in Arabidopsis

MKK6 controls T3-mediated browning of white adipose tissue

The bacterial effector HopZ1a acetylates MKK7 to suppress plant immunity

βC1 protein encoded in geminivirus satellite concertedly targets MKK2 and MPK4 to counter host defense

MKK4/MKK5-MPK1/MPK2 cascade mediates SA-activated leaf senescence via phosphorylation of NPR1 in Arabidopsis

EDR1 physically interacts with MKK4/MKK5 and negatively regulates a MAP kinase cascade to modulate plant innate immunity

Mefunidone ameliorates acute liver failure in mice by inhibiting MKK4-JNK pathway

The YDA-MKK4/MKK5-MPK3/MPK6 Cascade Functions Downstream of the RGF1-RGI Ligand–Receptor Pair in Regulating Mitotic Activity in Root Apical Meristem

(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD

A novel methuosis inducer DZ-514 possesses antitumor activity via activation of ROS-MKK4-p38 axis in triple negative breast cancer

Histone deacetylase 6 promotes growth of glioblastoma through the MKK7/JNK/c‐Jun signaling pathway

MicroRNA-145 attenuates TNF-α-driven cartilage matrix degradation in osteoarthritis via direct suppression of MKK4

Phosphatidic acid promotes the activation and plasma membrane localization of MKK7 and MKK9 in response to salt stress

The Raf‐like MAPKKKs STY8, STY17, and STY46 negatively regulate Botrytis cinerea resistance by limiting MKK7 protein accumulation in Arabidopsis

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