Details

Autor(en) / Beteiligte

• Contreras, Laura E. Sánchez
• Zirzlmeier, Johannes
• Kirner, Sabrina V.
• Setaro, Francesca
• Martínez, Fernando
• Lozada, Stefany
• Escobar, Patricia
• Hahn, Uwe
• Guldi, Dirk M.
• Torres, Tomás

Titel

Cholesteryl oleate-appended phthalocyanines as potential photosensitizers in the treatment of leishmaniasis

Ist Teil von

• Journal of porphyrins and phthalocyanines, 2015-01, Vol.19 (1n03), p.320-328

Ort / Verlag

Singapore: World Scientific Publishing Company

Erscheinungsjahr

2015

Beschreibungen/Notizen

• Two phthalocyanines (Pcs) with either a zinc or a ruthenium metal at the center of the macrocycle have been functionalized by a cholesteryl oleate moiety. The potential photosensitizers (PSs) for the treatment of cutaneous leishmaniasis have been studied on their photophysical properties and their ability to generate singlet oxygen. These experiments corroborate that solvent mixtures containing variable ratios of THF and water impact the excited state deactivation. The compounds were used preloaded into LDL particles and their phototoxic activity was evaluated in a preliminary way. Two phthalocyanines (Pcs), of zinc and ruthenium, have been functionalized by cholesteryl oleate groups as potential photosensitizers (PSs) for photodynamic therapy (PDT) against lieshmania. The photophysical characterization and their ability to photosynsetize singlet oxygen (1O2) of these potentially new photosensitizers (PSs) is provided. Their incubation into LDL particles and their toxicity and phototoxic activity have been assessed by in vitro prelimiry studies on intracellular amastigotes of L. panamensis parasites and mammalian tumoral human monocytic cell line THP-1.