Details

Autor(en) / Beteiligte

• Kuno, Toshiki
• Numasawa, Yohei
• Sawano, Mitsuaki
• Katsuki, Toshiomi
• Kodaira, Masaki
• Ueda, Ikuko
• Suzuki, Masahiro
• Noma, Shigetaka
• Negishi, Koji
• Ishikawa, Shiro
• Miyata, Hiroaki
• Fukuda, Keiichi
• Kohsaka, Shun

Titel

Abstract 11154: Effects of Body Habitus on Contrast-Induced Acute Kidney Injury After Percutaneous Coronary Intervention

Ist Teil von

• Circulation (New York, N.Y.), 2018-11, Vol.138 (Suppl_1 Suppl 1), p.A11154-A11154

Ort / Verlag

by the American College of Cardiology Foundation and the American Heart Association, Inc

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• IntroductionLimiting ratio of contrast volume to creatinine clearance (V/CrCl) is crucial to prevent contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary interventions (PCI). However, incidence of CI-AKI and distribution of V/CrCl may vary according to patients’ body habitus. We aimed to identify clinical factors for CI-AKI in patients with different body mass index (BMIs).HypothesisWe hypothesized patients with lower BMI were susceptible to V/CrCl>3.MethodsWe evaluated 8782 consecutive PCI patients. CI-AKI was defined as an absolute increase of 0.3 mg/dl or a relative increase of 50% in serum creatinine. Effect of V/CrCl for CI-AKI was evaluated within lower (≤25) and higher (>25) BMI groups, with V/CrCl>3 considered to be a risk factor for CI-AKI.ResultsV/CrCl>3 was a predictive of CI-AKI for regardless of BMI (OR, 1.77 [1.42-2.21]; P<0.001 for lower; and OR, 1.67 [1.22-2.29]; P=0.001 for higher BMI group). The relationship between BMI and CI-AKI followed a reversed J-curve relationship, albeit baseline renal dysfunction (creatinine clearance<60ml/min, 46.9% vs. 21.5%) and V/CrCl>3 (37.3% vs. 20.4%) were observed predominantly in lower BMI group; indeed, a low BMI was a significant predictor of V/CrCl>3 (OR per unit decrease in BMI, 1.08 [1.05-1.10]; P<0.001).ConclusionV/CrCl>3 was strongly associated with occurrence of CI-AKI. Importantly, we also identified a tendency for physicians to use higher V/CrCl in lean patients and recognition of these trends provides potential therapeutic targets to reduce incidences of CI-AKI.