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The FASEB journal, 1989-06, Vol.3 (8), p.1927-1932
Erscheinungsjahr
1989
Link zum Volltext
Beschreibungen/Notizen
Of 600 carotenoids from natural sources that have been characterized, fewer than 10% serve as precursors of vitamin A. Many dietary carotenoids, both with and without provitamin A activity, are found in the blood and tissues of humans. β‐Carotene, the most nutritionally active carotenoid, comprises 15‐30% of total serum carotenoids. Vitamin A is formed primarily by the oxygen‐dependent central cleavage of β‐carotene and other provitamin A carotenoids. Several carotenoids show enhancement of the immune response, inhibition of mutagenesis, reduction of induced nuclear damage, and protection from various neoplastic events in cells, tissues, and whole animals. Carotenoids also protect against photo‐induced tissue damage. Some carotenoids, including β‐carotene, quench highly reactive singlet oxygen under certain conditions and can block free radical‐mediated reactions. In epidemiological studies, the intake of carotenoid‐rich fruits and vegetables has been correlated with protection from some forms of cancer, particularly lung cancer. Similarly, serum β‐carotene levels have been associated with a decreased chance of developing lung cancer. It must be stressed, however, that these epidemiological associations do not show cause and effect. In this regard, long‐term intervention trials with β‐carotene supplements are in progress. Whatever the results of these trials, carotenoids clearly show biological actions in animals distinct from their function as precursors of vitamin A.—Bendich, A.; Olson, J. A. Biological actions of carotenoids. FASEB J. 3: 1927‐1932; 1989.