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Beschreibungen/Notizen
Transport of 2,4‐dinitrophenyl‐S‐glutathione (DNP‐SG) and a fluorescent glutathione S‐conjugate, bimane‐S‐glutathione (B‐SG) was studied in the baker's yeasts (S. cerevisiae). Both conjugates were exported from the cells; the transport was inhibited by fluoride and vanadate like in mammalian cells. B‐SG was also found to be accumulated in the vacuoles. The transport rate of DNP‐SG outside the cell was higher in a vacuolar‐deficient strain. A significant ATP‐dependent uptake of (3H)‐DNP‐SG by vacuoles was found. These results indicate thatS. cerevisiaetransport glutathione S‐conjugates both outside the cells and into the vacuoles.