Details

Autor(en) / Beteiligte

• Carreño, M. Carmen
• Hernández-Torres, Gloria
• Urbano, Antonio
• Colobert, Françoise

Titel

Sulfoxide-Directed Stereocontrolled Access to 2H-Chromans: Total Synthesis of the (S,R,R,R)-Enantiomer of the Antihypertensive Drug Nebivolol

Ist Teil von

• European Journal of Organic Chemistry, 2008-04, Vol.2008 (12), p.2035-2038

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2008

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A homochiral sulfoxide‐directed reductive deoxygenation of 2‐(p‐tolylsulfinyl)methyl‐2‐chromanols allows the stereoselective formation of 2H‐chromans with up to 95:5 diastereoisomeric ratio. This new methodology was appliedin a short and convergent enantioselective synthesis ofthe (S,R,R,R)‐enantiomer of the antihypertensive drugNebivolol.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) A homochiral sulfoxide‐directed reductive deoxygenation of 2‐(p‐tolylsulfinyl)methyl‐2‐chromanols (I) allows the stereoselective formation of 2H‐chromans with up to 95:5 dr. This new methodology was applied in a short and convergent enantioselective synthesis of the (S,R,R,R)‐enantiomer of the antihypertensive drug Nebivolol.