Details

Autor(en) / Beteiligte

• Shiina, Junichi
• Obata, Rika
• Tomoda, Hiroshi
• Nishiyama, Shigeru

Titel

Synthesis of Chiloscyphones and the Biological Activities of Their Synthetic Intermediates Against Methicillin-Resistant Staphylococcus aureus (MRSA)

Ist Teil von

• European Journal of Organic Chemistry, 2006, Vol.2006 (10), p.2362-2370

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2006

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The total syntheses of chiloscyphone (1) and isochiloscyphone (2) have been achieved. Furthermore, the synthetic intermediate 5 shows biological activity against methicillin‐resistant Staphyrococcus aureus, and compounds 5, 17, and 18, display imipenem‐type activity. The tricyclic lactone framework, which includes an α,β‐unsaturated ketone moiety, might play a crucial role in the anti‐MRSA activity. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)