Details

Autor(en) / Beteiligte

• Niess, Barbara
• Hartung, Ingo V.
• Haustedt, Lars O.
• Hoffmann, H. Martin R.

Titel

Synthesis of a Tetradehydro-Disorazole C1

Ist Teil von

• European Journal of Organic Chemistry, 2006, Vol.2006 (5), p.1132-1143

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2006

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The synthesis of a protected 9,9′,10,10′‐tetradehydro‐disorazole C1 is described. A C1–C8 oxazole fragment with an E‐vinylic iodide terminus is coupled to a suitable C9–C19 enyne. The resulting ω‐hydroxycarboxylic acid is cyclodimerized stepwise via intermolecular esterification, followed by lactonization. In addition, simplified masked analogues of disorazole C1 with truncated side chains are prepared. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)