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Intensity‐modulated chemoradiation for treatment of stage III and IV oropharyngeal carcinoma
Cancer, 2008-08, Vol.113 (3), p.497-507
Huang, Kim
Xia, Ping
Chuang, Cynthia
Weinberg, Vivian
Glastonbury, Christine M.
Eisele, David W.
Lee, Nancy Y.
Yom, Sue S.
Phillips, Theodore L.
Quivey, Jeanne M.
2008
Details
Autor(en) / Beteiligte
Huang, Kim
Xia, Ping
Chuang, Cynthia
Weinberg, Vivian
Glastonbury, Christine M.
Eisele, David W.
Lee, Nancy Y.
Yom, Sue S.
Phillips, Theodore L.
Quivey, Jeanne M.
Titel
Intensity‐modulated chemoradiation for treatment of stage III and IV oropharyngeal carcinoma
Ist Teil von
Cancer, 2008-08, Vol.113 (3), p.497-507
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2008
Link zum Volltext
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
BACKGROUND. Treatment outcomes for stage III and IV oropharyngeal carcinoma treated with intensity‐modulated radiotherapy (IMRT) and concurrent chemotherapy without prior surgical resection were reviewed. METHODS. Between April 2000 and September 2004, 71 patients underwent IMRT concurrent with chemotherapy without prior surgical resection for stage III and IV oropharyngeal carcinoma. Chemotherapy was platinum based. The gross tumor volume (GTV) received 70 Gy in 2.12 Gy per fraction. The high‐risk clinical tumor volume (CTV) received 59.4 Gy in 1.80 Gy per fraction, and the low‐risk CTV received 54 Gy in 1.64 Gy per fraction. RESULTS. With a median follow‐up of 33 months, the 3‐year local, regional, and locoregional progression‐free probabilities were 94%, 94%, and 90%, respectively. The 3‐year overall survival estimate was 83%. Locoregional failures occurred in the GTV in 7 patients. Acute grade 3 or 4 toxicity developed in 35 patients. A feeding gastrostomy was placed in 25 patients. Late xerostomia was grade 0 in 16 patients, grade 1 in 31 patients, and grade 2 in 24 patients at last follow‐up. No patients experienced grade 3 or 4 late toxicity, except for 1 who developed osteoradionecrosis of the mandible. CONCLUSIONS. Excellent local and regional control was achieved with IMRT and concurrent chemotherapy without prior surgical resection in the treatment of stage III and IV oropharyngeal carcinoma. Significant sparing of the parotid glands and other critical normal tissues was possible using IMRT with moderate acute toxicities and minimal severe late effects. Cancer 2008. © 2008 American Cancer Society. Intensity‐modulated radiotherapy and concurrent chemotherapy without prior surgical resection resulted in excellent local and regional control in 71 patients with stage III and IV oropharyngeal carcinoma. There was significant sparing of the parotid glands and other critical normal tissues, with moderate acute toxicities and minimal severe late effects.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.23578
Titel-ID: cdi_wiley_primary_10_1002_cncr_23578_CNCR23578
Format
–
Schlagworte
chemotherapy
,
cisplatin
,
head and neck cancer
,
intensity‐modulated radiotherapy
,
locally advanced
,
oropharyngeal carcinoma
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