Details

Autor(en) / Beteiligte

• Eisermann, Jana
• Liang, Yuxin
• Wright, John J.
• Clifford, Eleanor
• Wilton‐Ely, James D. E. T.
• Kuimova, Marina K.
• Roessler, Maxie M.

Titel

Cover Feature: The Effect of Reactive Oxygen Species on Respiratory Complex I Activity in Liposomes (Chem. Eur. J. 55/2024)

Ist Teil von

• Chemistry : a European journal, 2024-10, Vol.30 (55), p.n/a

Erscheinungsjahr

2024

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• The enzyme respiratory complex I is a major contributor to reactive oxygen species (ROS) in mitochondria. How complex I produces ROS has been investigated extensively. However, it has been difficult to understand the downstream effect of these ROS. Here, researchers put complex I into artificial membrane vesicles doped with spin‐labelled lipids to “spy” on the ROS by using EPR spectroscopy. They show that reversible changes in the membrane, caused by ROS, decrease complex I activity. More information can be found in the Research Article by M. M. Roessler and co‐workers (DOI: 10.1002/chem.202402035).