Details

Autor(en) / Beteiligte

• Subramanian , Ganapathy
• Subramanian, Ganapathy

Titel

Single-Use Systems Support Continuous Bioprocessing by Perfusion Culture

Ist Teil von

• Continuous Processing in Pharmaceutical Manufacturing, 2014, p.183-226

Ort / Verlag

Germany: Wiley

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Wiley Online Library All Obooks

Beschreibungen/Notizen

• Continuous processing is a well‐established and fundamental mode of modern manufacturing. Recent trends in manufacturing demands synergize with many of the single‐use (SU) and continuous biomanufacturing (CB) values and features. The recent heightened interest in CB is coincident with the maturing of SU manufacturing, and a growing number of biopharmaceutical companies currently employ some CB‐enabling and/or SU operations. It is important to consider that continuous processing, including perfusion culture, can place increased or unique pressures upon manufacturing systems, and especially for single‐use systems. Roller bottle systems of many styles have traditionally been the most popular bioreactor system for the production of biologics and viruses using adherent cells. Packed bed (PB) bioreactors provide yet another approach to a continuous culture enabling upstream process. In mechanically agitated bioreactors, suspension or matrix‐attached cultures are agitated through a number of mechanical mechanisms, from marine impellers to paddles to airwheels.