Details

Autor(en) / Beteiligte

• Huang, George T.‐J
• El Ayachi, Ikbale
• Zou, Xiao‐Ying
• Waddington, Rachel J
• Sloan, Alastair J

Titel

Induced pluripotent stem cell technologies for tissue engineering

Ist Teil von

• Tissue Engineering and Regeneration in Dentistry, 2016, p.1-19

Ort / Verlag

United Kingdom: John Wiley & Sons, Incorporated

Erscheinungsjahr

2016

Quelle

Wiley Online Library All Obooks

Beschreibungen/Notizen

• Induced pluripotent stem cells (iPSCs) were first established by delivering the four factors c‐Myc/Klf4/Oct4/Sox2 or Lin28/Nanog/Oct4/Sox2 into dermal fibroblasts via a viral vector‐based approach. While many aspects of iPSCs require investigation concerning their clinical safety, utilising iPSCs for cell therapy is anticipated to take place in the future. This chapter focuses on cell‐based tissue regeneration and generation of patient‐specific iPSCs to study disease mechanisms. It provides an overview of current progress in this area, particularly emphasising neurogenesis. Additionally, utilising iPSCs as a tool for studying genetics and disease mechanisms are also be reviewed. Osteogenic differentiation of iPSCs for bone tissue regeneration has been reported using scaffolds such as macro‐channeled polycaprolactone scaffolds, polyethersulfone nanofibrous scaffolds and fibrin or hydroxyapatite/p‐tricalcium phosphate. iPSC‐derived cardiomyocytes have been engrafted successfully into the hearts of experimental animals and used to improve cardiac function after ischemic cardiomyopathy in a porcine model.