Details

Autor(en) / Beteiligte

• Singh, Rajesh K
• Haka, Abigail S
• Maxfield, Frederick R
• Lu, Shuyan
• Willard, James M

Titel

Lysosome Exocytosis and Membrane Repair

Ist Teil von

• Lysosomes: Biology, Diseases, and Therapeutics, 2016, p.63-85

Ort / Verlag

Hoboken, NJ, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2016

Quelle

Wiley Online Library All Obooks

Beschreibungen/Notizen

• This chapter presents the functions and mechanisms of lysosome exocytosis and membrane repair. Lysosome exocytosis plays an important role in diverse biological processes such as plasma membrane repair following mechanical or bacterial cellular damage, immune responses, parasite entry into cells, bone remodeling, phagocytosis of large particles, and extracellular degradation of disease‐associated substrates. Thus, the role of lysosomes in cellular biology has been expanded, and, in addition to the conventional view that lysosomes are terminal compartments of the endocytic pathway, it is now accepted that lysosomes behave as regulated secretory vesicles. While current understanding of the secretory machinery regulating lysosome exocytosis is limited, it is clear that elucidation of such mechanisms will have direct significance for human health. Discoveries may offer new strategies and drug targets for the prevention and treatment of a wide array of human diseases.