Details

Autor(en) / Beteiligte

• Jiang, Kewei
• Lyu, Liang
• Shen, Zhanlong
• Zhang, Jizhun
• Zhang, Hui
• Dong, Jianqiang
• Yan, Yichao
• Liu, Fangfang
• Wang, Shan

Titel

Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer

Ist Teil von

• Chinese medical journal, 2014-06, Vol.127 (11), p.2021-2024

Ort / Verlag

China: Department of General Surgery, Qingdao University Affiliated Hospital, Qingdao, Shandong 266000, China%Central Laboratory, Peking University People's Hospital, Beijing 100044, China

Erscheinungsjahr

2014

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Background Sirtuin 1 （SIRT1） has been reported to have diverse roles in various biological processes through deacetylation of histone and nonhistone proteins.However,the correlations among SIRT1 protein expression,clinicopathological parameters,and survival of colorectal cancer patients remain unclear.Methods SIRT1 protein expression was measured by immunohistochemistry in a paraffin-embedded tissue microarray,including 120 paired colorectal cancer and normal mucosa tissues.The correlations among SIRT1 protein expression,clinicopathological features,and prognosis were analyzed.Results All samples （100%） were positive for SIRT1,with variable staining in the cytoplasm rather than in the nucleus.There was significant difference in SIRT1 overexpression between adenocarcinomas and normal mucosal tissue （P〈0.01,x2 test）.SIRT1 overexpression was more frequently observed in advanced-stage tumors （P=0.046,0.002,x2test）.SIRT1 overexpression was significantly correlated with poor overall survival （P=0.013,log-rank test） and diseasefree survival （P=0.012,log-rank test）.Conclusions SIRT1 overexpression correlated with advanced stage and poor prognosis.SIRT1 may play an important role in the progression of colorectal cancer.