Details

Autor(en) / Beteiligte

• Lü, Wei
• Yang, Hai-Hong
• Fan, Yun-Ming
• Li, Takming
• Zhang, Li-Fan
• Mui, Chongseong
• Fan, Hong-Wei
• Zhou, Bao-Tong
• Liu, Zheng-Yin
• Ng, Hou
• Liu, Xiao-Qing

Titel

Serum HBV DNA level at week 12 is superior to viral response at week 24 in predicting long-term treatment outcome of telbivudine for chronic hepatitis B patients

Ist Teil von

• Chinese medical journal, 2013-06, Vol.126 (12), p.2333-2336

Ort / Verlag

China: Department of Infectious Diseases, Peking Union Medical College Hospital, Beijing 100730, China%Department of Infectious Diseases, First Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong 510120, China%Department of Internal Medicine, Common Hospital Centre S.Januario, Macau, China

Erscheinungsjahr

2013

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Background Telbivudine,one of the five nucleos（t）ide antiviral drugs,was reported to be superior to lamivudine in a better biochemical,virological,and histological response for treatment-naive patients in the GLOBE trial.The aim of this study was to determine the antiviral potency,viral resistance,and the significance of early response for long-term telbivudine treatment.Methods We recruited 161 patients of chronic hepatitis B （CHB） on telbivudine between January 2009 and September 2011 in Macau,China.The serum hepatitis B virus DNA levels,hepatitis B e antigen （HBeAg） seroconversion,alanine aminotransferese （ALT） normalization,and viral resistance were analyzed.Results The median age and follow-up duration were 48 years and 16.9 months.All patients were followed up for at least 6 months,while data were collected for 132,120,95,and 53 patients at 12,24,48,and 96 weeks respectively.The cumulative HBeAg seroconversion rate was 20.8% and only three patients （1.9%） presented with telbivudine low level resistance.The ALT normalization rates were 76.9% at 48 weeks and 77.6% at 96 weeks.Undetectable HBV DNA was achieved by 1.8%,31.6%,60%,and 74.1% in HBeAg positive patients and 29.3%,60.3%,84%,and 84.6% in HBeAg negative patients at each time point.Week 12 HBV DNA level 〈1000 copies/ml （〈200 IU/ml） was a better predictor of viral suppression at 2-year follow-up （P=-0.001,OR=27.00） than undetectable HBV DNA level at week 24 （P=0.120,OR=4.81）.Conclusions Two-year telbivudine treatment yielded high rates of viral suppression and ALT normalization.Serum HBV DNA level at week 12 is a superior predictor for long-term viral suppression.