Details

Autor(en) / Beteiligte

• Ye, Feng
• He, Li-Xian
• Cai, Bo-Qiang
• Wen, Fu-Qiang
• Chen, Bai-Yi
• Hadiarto, Mangunnegoro
• Chen, Rong-Chang
• Yuan, Jin-Ping
• Sun, Hong-Li

Titel

Spectrum and antimicrobial resistance of common pathogenic bacteria isolated from patients with acute exacerbation of chronic obstructive pulmonary disease in mainland of China

Ist Teil von

• Chinese medical journal, 2013-06, Vol.126 (12), p.2207-2214

Ort / Verlag

China: Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou,Guangdong 510120, China%Department of Respiratory Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China%Department of Respiratory Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China%Department of Respiratory Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China%Department of Infectious Disease, First Hospital of China Medical University, Shenyang, Liaoning 110001, China%Department of Respiratory Diseases, Faculty of Medicine, University of Indonesia, USA

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Bacteria-induced respiratory infection has been long considered to be the major cause of acute exacerbation of chronic obstructive pulmonary disease （AECOPD）.Therefore,a clear picture about the distribution and drug-resistance of pathogenic bacteria in the lower airways should be helpful for treatment of the disease.So far,data on this topic among Chinese are lacking.Methods A surveillance study was performed in consecutive patients with AECOPD at five areas in China between October 2006 and April 2008.The sputum from these patients was cultured and isolated for bacteria.Agar dilution method was used to determine the minimal inhibitory concentrations （MICs） of levofloxacin and other 15 antibiotics against these strains.Results Three hundred and fifty-nine pathogenic bacterial strains were isolated among 884 patients with AECOPD.The predominant bacteria were Pseudomonas aeruginosa （21.7%）,Klebsiella pneumoniae （12.3%）,Haemophilus influenzae （14.2%） and Streptococcus pneumoniae （11.7%）,followed by Haemophilus parainfluenzae （9.5%）,Acinetobacter baumannii （7.8%）,Moraxella catarrhalis （6.4%） and Escherichia coli （3.6%）.The majority of bacterial pathogens isolated in this study were susceptible to fluoroquinolones,ceftazidime,cefepime and imipenem.Conclusions Gram-negative bacilli are the leading pathogens in patients with AECOPD in China.Haemophilus parainfluenzae may be one of the most important pathogens in AECOPD.This study provides evidence for local surveillance of AECOPD pathogens and appropriate choice of antimicrobials in China.