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Autor(en) / Beteiligte
Titel
Characterization of erythromycin-resistant Streptococcus pneumoniae isolates causing invasive diseases in Chinese children
Ist Teil von
  • Chinese medical journal, 2013, Vol.126 (8), p.1522-1527
Ort / Verlag
China: Key Laboratory of Major Diseases in Children and the National Key Discipline of Pediatrics(Capital Medical University),Ministry of Education, Beijing Pediatrics Research Institute,Beijing Children's Hospital, Beijing 10045, China%Lanzhou Institute of Biological Products, Lanzhou, Gansu 730030,China%Shenzhen Children's Hospital, Shenzhen, Guangdong 518000,China%Pediatric Hospital of Fudan University, Shanghai 200102, China%Shengjing Hospital Affiliated to China Medical University,Shenyang, Liaoning 110100, China%Nanjing Children's Hospital, Nanjing, Jiangsu 210000, China
Erscheinungsjahr
2013
Quelle
MEDLINE
Beschreibungen/Notizen
  • Background Erythromycin-resistant Streptococcus pneumoniae isolates that causing invasive pneumococcal diseases (IPD) in Chinese children remain uncharacterized. This study aims to identify the resistance genes associated with erythromycin resistance and to determine the genetic relationships of IPD isolates in Chinese children. Methods A total of 171 S. pneumoniae strains were isolated from 11 medical centers in China from 2006 to 2008. All the isolates were characterized via serotyping and antibiotic susceptibility determination. The erythromycin-resistant isolates were further characterized via ermB and mefA gene detection, multi-locus sequence typing analysis, and pulsed-field gel electrophoresis. Results A total of 164 (95.9%) isolates showed resistance to erythremycin, of which 162 strains with high high-level resistance (MIC 〉 256 pg/ml). A total of 104 (63.4%) isolates carry the ermB gene alone, whereas 59 (36.0%) harbor both ermB and mefA genes. Of the 59 strains, 54 were of serotypes 19A and 19F and were identified as highly clonal and related to the TaiwanlgF-14 clone. Conclusions The erythromycin resistance rate in IPD isolates is significantly high and is predominantly mediated by the ermB aene. Isolates that carrv both ermB and mefA Qenes are oredominantlv of serotvoes 19A and 19E

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