Details

Autor(en) / Beteiligte

• Zhu, Yao-bin
• Zhang, Yan-bo
• Liu, Dong-hai
• Li, Xiao-feng
• Liu, Ai-jun
• Fan, Xiang-ming
• Qiao, Chen-hui
• Ling, Feng
• Liu, Ying-long

Titel

Atrial natriuretic peptide attenuates inflammatory responses on oleic acid-induced acute lung injury model in rats

Ist Teil von

• Chinese medical journal, 2013-02, Vol.126 (4), p.747-750

Ort / Verlag

China: Department of Pediatric Heart Center, Beijing Anzhen Hospital,Capital Medical University, Beijing 100029, China%Department of Pediatric Heart Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China%Department of Cardiovascular Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China

Erscheinungsjahr

2013

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Background An inflammatory response leading to organ dysfunction and failure continues to be a major problem after injury in many clinical conditions such as sepsis, severe burns, and trauma. It is increasingly recognized that atrial natriuretic peptide （ANP） possesses a broad range of biological activities, including effects on endothelial function and inflammation. A recent study has revealed that ANP exerts anti-inflammatory effects. In this study we tested the effects of human ANP （hANP） on lung injury in a model of oleic acid （OA）-induced acute lung injury （ALl） in rats. Methods Rats were randomly assigned to three groups （n=6 in each group）. Rats in the control group received a 0.9% solution of NaCI （1 ml-kg-l.h1） by continuous intravenous infusion, after 30 minutes a 0.9% solution of NaCI （1 ml/kg） was injected intravenously, and then the 0.9% NaCI infusion was restarted. Rats in the ALl group received a 0.9% NaCI solution （1 ml-kgl-h-~） intravenous infusion, after 30 minutes OA was injected intravenously （0.1 ml/kg）, and then the 0.9% NaCI infusion was restarted. Rats in the hANP-treated ALl group received a hANP （0.1 IJg.kg-Lmin~） infusion, after 30 minutes OA was injected intravenously （0.1 ml/kg）, and then the hANP infusion was restarted. The anti-inflammation effects of hANP were evaluated by histological examination and determination of serum cytokine levels. Results Serum interleukin （IL）-113, IL-6, IL-10 and tumor necrosis factor （TNF） a were increased in the ALl group at six hours. The levels of all factors were significantly lower in the hANP treated rats （P 〈0.005）. Similarly, levels of IL-113, IL-6, IL-10 and TNF-a were higher in the lung tissue in the ALl group at six hours, hANP treatment significantly reduced the levels of these factors in the lungs （P 〈0.005）. Histological examination revealed marked reduction in interstitial congestion, edema, and inflammation. Conclusion hANP can attenuate inflammation in OA-induced lung injury in rat model.