Details

Autor(en) / Beteiligte

• Gao, Zhan
• Xu, Bo
• Kirtane, Ajay J
• Yang, Yue-jin
• Yuan, Jin-qing
• Chen, Ji-lin
• Qiao, Shu-bin
• Wu, Yong-jian
• Qin, Xue-wen
• Yan, Hong-bin
• Yao, Min
• Liu, Hai-bo
• Chen, Jue
• You, Shi-jie
• Gao, Run-lin

Titel

Impact of depressed left ventricular function on outcomes in patients with three-vessel coronary disease undergoing percutaneous coronary intervention

Ist Teil von

• Chinese medical journal, 2013-02, Vol.126 (4), p.609-614

Ort / Verlag

China: Cardiovascular Institute & Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing100037,China%Columbia University Medical Center/New York-Presbyterian Hospital, New York, NY, USA

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Patients with multivessel coronary artery disease and depressed left ventricular ejection fraction （LVEF） represent a high risk group of patients for coronary revascularization. There are limited data on percutaneous coronary intervention treatment in this population. Methods Among a cohort of 4335 patients with three-vessel disease with or without left main disease undergoing percutaneous coronary intervention, 191 patients had LVEF 〈40% （low ejection fraction （EF）） and 4144 patients had LVEF _〉40%. In-hospital and long-term outcomes were examined according to LVEF. Results The estimated two-year rates of major adverse cardiac events, cardiac death, and myocardial infarction were significantly higher in the low EF group （19.64% vs. 8.73%, Log-rank test： P 〈0.01; 10.30% vs. 1.33%, Log-rank test： P 〈0.01, and 10.32% vs. 2.28%, Log-rank test： P 〈0.01 respectively）, but there was no difference in the rates of target vessel revascularization （6.18% vs. 6.11%, Log-rank test： P=0.96）. Using the Cox proportional hazard models, LVEF 〈40% was a significant risk factor for cardiac death, myocardial infarction, and major adverse cardiac events （OR （95% CI）： 4.779 （2.369-9.637）, 2.673 （1.353-5.282）, and 1.827 （1.187-2.813） respectively）, but was not a statistically significant risk factor for target vessel revascularization （OR （95% CI）： 1.094 （0.558-2.147））. Conclusion Among patients undergoing percutaneous coronary intervention for multivessel coronary artery disease, left ventricular dysfunction remains associated with further risk of cardiac death in-hospital and during long-term follow-up.