Details

Autor(en) / Beteiligte

• Su, Yin
• Zhao, Yi
• Liu, Xu
• Guo, Jian-Ping
• Jiang, Quan
• Liu, Xiang-Yuan
• Zhang, Feng-Chun
• Zheng, Yi
• Li, Xiao-Xia
• Song, Hui
• Huang, Ci-Bo
• Huang, Yan-Hong
• Wang, Tian
• Pan, Si-Si
• Li, Chun
• Liu, Xia
• Zhu, Lei
• Zhang, Chun-Fang
• Li, Zhan-Guo

Titel

Variation in STAT4 is associated with systemic lupus erythematosus in Chinese Northern Han population

Ist Teil von

• Chinese medical journal, 2010-11, Vol.123 (22), p.3173-3177

Ort / Verlag

China: Department of Rheumatology & Immunology/Clinical Immunology Center Peking University People's Hospital,Beijing 100044,China%Department of Rheumatology & Immunology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China%Department of Rheumatology & Immunology,Peking University Third Hospital,Beijing 100191,China%Department of Rheumatology & Immunology,Peking Union Medical College Hospital,Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing 100730,China%Department of Rheumatology & Immunology,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China%Department of Rheumatology & Immunology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China%Department of Rheumatoiogy & Immunology,Beijing Jishuitan Hospital,Beijing 100035,China%Department of Rheumatology & Immunology,Beijing Hospital,Beijing 100730,China%Department of Rheumatology & Immunology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China%Department of Clinical Epidemiology Peking University People's Hospital,Beijing 100044,China

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Recent studies have identified signal transducer and activator of transcription 4 （STAT4） as a susceptibility gene for systemic lupus erythematosus （SLE） in different populations. In order to examine whether the allele distribution of the single nucleotide polymorphism （SNP） in gene STAT4 rs7574865 in patients with SLE is different from those of healthy controls in Chinese Northern Han population, we investigated whether the variants of STAT4 rs7574865 were associated with any specific clinical features of SLE. Methods We genotyped SNPs in STAT4 rs7574865 in 252 patients with SLE and 497 healthy controls. All subjects were from the Northern part of Chinese Han population. The genotypes in rs7574865 were determined by polymerase chain reaction （PCR） and consequence direct sequencing of PCR products in the DNA samples. Results There was a significant difference in distribution of the SNPs in rs7574865 between the SLE patients and healthy controls. Compared with healthy controls, there was a significant correlation between TT genotypes in rs7574865 and the risk of SLE when GG genotype was used as a reference genotype after adjusting for gender and age. The frequency of T allele in the SLE patients was strongly significantly higher than that of healthy controls. Furthermore, there was a significant difference in the distribution of SNP in rs7574865 between male and female SLE patients, when compared with healthy controls. The frequency of T allele in rs7574865 in male patients was significantly higher than that of male healthy controls or female patients. There was no significant correlation between the frequencies of T allele in STAT4 rs7574865 and the clinical features of SLE. Conclusions The SNP rs7574865 in STAT4 is strongly associated with risk of SLE in the Chinese Northern Hart population. The TT genotype and T allele in STAT4 rs7574869 are susceptibility factors for SLE, especially for male SLE patients.