Details

Autor(en) / Beteiligte

• Duan, Chun-guang
• Liu, Yan-fang
• Li, Kai-nan
• Yu, Lu
• Cui, Ji-hong
• Li, Jing
• Yang, Shou-jing

Titel

Co-localization of the heat shock protein and human immunoglobulin G in hepatocellular carcinoma

Ist Teil von

• Chinese medical journal, 2005-12, Vol.118 (23), p.2011-2013

Ort / Verlag

China: Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China

Erscheinungsjahr

2005

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• Elevated levels of serum immunoglobulin observed in patients with cancers of epithelial origin, including carcinomas of breast, colon, and liver have been interpreted as humoral responses of host to cancer growth. Recently, Qiu et al described in detail that human cancers of epithelial origin, including carcinomas of breast, colon, liver, lung, established epithelial cancer lines, produce immunoglobulin G （IgG） in their cytoplasm. Under normal conditions, heat shock proteins （HSPs） have multiple cellular functions, such as folding and translocating newly synthesized proteins. When a cell is injured or under stress, HSPs refold damaged protein or facilitate degradation of proteins. In most cancers, heat shock proteins can capture tumour specific peptide to inhibit the growth of cancer. This study demonstrated that human IgG and HSPs are co-localized in hepatocellular carcinoma.