Details

Autor(en) / Beteiligte

• Li, Feng
• Zhang, Guibin
• Zhao, Wenzhou

Titel

Coagulation and fibrinolytic activity in patients with acute cerebral infarction

Ist Teil von

• Chinese medical journal, 2003-03, Vol.116 (3), p.475-477

Ort / Verlag

China: Department of Neurology, People's Hospital, Wuhan University, Wuhan 430060, China%Department of Neurology, First People's Hospital of Xiangfan, Hubei Province 441000, China

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• To measure the concentration of D-dimer (DD), tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1) and plasminogen (PLG) activity in plasma and cerebrospinal fluid in patients with acute cerebral infarction and to investigate their clinical significance. The concentrations of D-dimer, t-PA, and PAI-1 in plasma and cerebrospinal fluid in patients were measured by enzyme-linked immunosorbent assay (ELISA). The PLG biological activity was detected using the chromophore method. The results were compared with those of the controls. The concentrations of D-dimer, t-PA and PAI-1 in cerebrospinal fluid and plasma in patients with acute cerebral infarction were much higher than those of normal subjects (P < 0.01). Conversely, the level of PLG activity was significantly lower in the patients than in the controls (P < 0.01). Hypercoagulability and secondary hyperfibrinolysis exist in patients with acute cerebral infarction.