Details

Autor(en) / Beteiligte

• Weibing Shuang Qiang Liu Shoubin Jiao Yang Yang

Titel

Establishment and validation of standardized animal models of spinal cord injury by normal external force-caused fracture dislocation

Ist Teil von

• 中国神经再生研究（英文版）, 2011-12, Vol.6 (35), p.2732-2738

Ort / Verlag

Department of Urology, the Sixth Agricultural Division Hospital of Xinjiang Production and Construction Corps, Wujiaqu 831300, Xinjiang Uygur Autonomous Region,China%Department of Orthopedics, the First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China%Department of Urology, the First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China

Erscheinungsjahr

2011

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• The duplication of animal models plays a key role in spinal cord injury research; however, there has been limited study into normal, external force-derived fracture dislocation. This study adopted experimental devices, designed in-house, to construct standardized ventral and dorsal spinal cord injury animal models of 6 g and 17 g falling from a height of 2, 4, and 10 cm, and 15, 30 or 50 g transversal compression on the spinal cord. The results showed that gradual increases in the degree of histopathological injury led to decreased Tarlov and Basso, Beattie and Bresnahan scores for the behavioral test, and increased Ashworth scores for the hind limb. Furthermore, there was a gradual decline in the slope test in the rats with dorsal spinal cord injury that correlated to increases in the falling substance weight or falling height. Similar alterations were observed in the ventral spinal cord injured rats, proportional to the increase in compression weight. Our experimental findings indicate that the standardized experimental rat models of dorsal and ventral spinal cord injury are stable, reliable and reproducible.