Details

Autor(en) / Beteiligte

• Ning Wang Dongpi Wang Zhong LV Xuan Chen Long Lin Zhiyong Hu

Titel

Xuefuzhuyu decoction and astragalus prevent hypoxic-ischemic brain injury

Ist Teil von

• 中国神经再生研究（英文版）, 2011-07, Vol.6 (21), p.1635-1639

Ort / Verlag

Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China%Huqingyu Hall Traditional Chinese Medicine Museum, Hangzhou 310000, Zhejiang Province, China%Red Cross Hospital, Hangzhou 310000, Zhejiang Province,China

Erscheinungsjahr

2011

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Hypoxic-ischemic brain injury models were generated by bilateral carotid artery ligation in Sprague-Dawley rats. Successful models were treated with a combination of Xuefuzhuyu decoction and 10g of astragalus. The experimental results showed that neuronal morphology and structure recovered, nerve growth factor mRNA expression increased in brain tissues, and neurological function signifi-cantly improved. There was no significant difference in these measures compared with rats treated with Xuefuzhuyu decoction alone or a combined treatment of Xuefuzhuyu decoction with 40 g as-tragalus. These experimental findings revealed that, Xuefuzhuyu decoction combined with astra-galus may up-regulate the expression of nerve growth factor mRNA and accordingly exert a neu-roprotective effect; however, this protection is not dependent on astragalus dosage.