Details

Autor(en) / Beteiligte

• Wang, Qian-Qian
• Hu, Rong
• Fang, Zheng-Qi
• Shi, Guoyue
• Zhang, Shengqiang
• Zhang, Min

Titel

A multifunctional upconversion nanoparticles probe for Cu2+ sensing and pattern recognition of biothiols

Ist Teil von

• Chinese chemical letters, 2022-08, Vol.33 (8), p.3782-3786

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2022

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Lanthanide-doped upconversion nanoparticles (Ln-UCNPs) are a new type of nanomaterials with excellent fluorescence properties, which are well applied in fluorescent biosensing. Herein we developed a multifunctional probe based on the surface engineering of core-shell structure UCNPs with polyacrylic acid (PAA). The developed PAA/UCNPs probe could be highly selective to detect and respond to Cu2+ at different pH. Cu2+ could easily combine with the carboxylate anion of PAA to quench the fluorescence of UCNPs. Therefore, we creatively proposed a fluorescent array sensor (PAA/UCNPs-Cu2+), in which the same material acted as the sensing element by coupled with pH regulation for pattern recognition of 5 thiols. It could also easily identify the chiral enantiomer of cystine (l-Cys-and d-Cys), and distinguish their mixed samples with different concentrations, and more importantly, it could be combined with urine samples to detect actual level of homocysteine (Hcys) to provide a new solution for judging whether the human body suffers from homocystinuria. Herein, we developed a multifunctional probe based on the surface engineering of core-shell structure UCNPs with PAA to versatilely recognize Cu2+ and various metal ions. [Display omitted]