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Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation
Ist Teil von
Chinese chemical letters, 2020-02, Vol.31 (2), p.427-430
Ort / Verlag
Elsevier B.V
Erscheinungsjahr
2020
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Two new 9,10-seco and etherified abietane-type diterpenoids were isolated from Callicarpa bodinieri, and their structure were elucidated by detailed spectrometry data analysis and DP4+ NMR calculation methods.
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Callicarpa bodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic. Herein, we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids J and K (1 and 2) and one known compound (3) isolated from the leaves and twigs of this plant. Their chemical structures were elucidated by detailed spectrometry data analysis and DP4 + NMR calculation methods. Hypothetical biosynthetic pathways of 1−3 were preliminarily speculated. Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro.