Details

Autor(en) / Beteiligte

• Gao, Junbo
• Zhang, Xingjie
• Shang, Kun
• Zhong, Weimao
• Zhang, Ruihan
• Dai, Xiaochang
• Li, Xiaoli
• Wang, Qi
• Zou, Yan
• Xiao, Weilie

Titel

Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation

Ist Teil von

• Chinese chemical letters, 2020-02, Vol.31 (2), p.427-430

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Two new 9,10-seco and etherified abietane-type diterpenoids were isolated from Callicarpa bodinieri, and their structure were elucidated by detailed spectrometry data analysis and DP4+ NMR calculation methods. [Display omitted] Callicarpa bodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic. Herein, we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids J and K (1 and 2) and one known compound (3) isolated from the leaves and twigs of this plant. Their chemical structures were elucidated by detailed spectrometry data analysis and DP4 + NMR calculation methods. Hypothetical biosynthetic pathways of 1−3 were preliminarily speculated. Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro.