Details

Autor(en) / Beteiligte

• Lu, Ming-Dong
• Zhou, Xiao
• Yu, Yao-Jun
• Li, Pi-Hong
• Sun, Wei-Jian
• Zhao, Cheng-Guang
• Zheng, Zhi-Qiang
• You, Tao
• Wang, Fei-Hai

Titel

Synthesis and in vitro biological evaluation of nitric oxide-releasing derivatives of hydroxylcinnamic acids as anti-tumor agents

Ist Teil von

• Chinese chemical letters, 2013-05, Vol.24 (5), p.415-418

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2013

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Novel furoxan-based nitric oxide-releasing derivatives 6a-p of hydroxylcinnamic acids were synthesized by coupling the carboxyl group of hydroxylcinnamic acids with furoxan through various alkylol amines.Compounds 6a,e-i and m-p displayed more potent anti-tumor activities superior to control 5-fluorouracil（5-FU） in most cancer cells tested.Furthermore,6f could selectively inhibit tumor cells,but not non-tumor cell proliferation.This inhibition was attributed to high levels of NO released in cancer cells and potentially synergistic effect of NO donor moieties and the bioactivity of hydroxylcinnamic acids.