Chinese chemical letters, 2010-11, Vol.21 (11), p.1334-1337
2010
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Details
- Autor(en) / Beteiligte
- Titel
- An unexpected Hoffmann elimination during the alkylation of dihydrotetrabenazine
- Ist Teil von
- Chinese chemical letters, 2010-11, Vol.21 (11), p.1334-1337
- Ort / Verlag
- Elsevier B.V
- Erscheinungsjahr
- 2010
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Dihydrotetrabenazine（DTBZ） is the major pharmacologically active form of tetrabenazine（TBZ）,which was approved by FDA for the treatment of chorea associated with Huntington＇s disease（HD）.An unexpected Hoffmann elimination was observed during the treatment of DTBZ with sodium hydrogen and alkyl halides,leading to the formation of both eliminated products（major） and hydroxyl-alkylated products（minor）.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1001-8417eISSN: 1878-5964DOI: 10.1016/j.cclet.2010.06.022Titel-ID: cdi_wanfang_journals_zghxkb201011019
- Format
- –
- Schlagworte
- Alkylation, Dihydrotetrabenazine, Hoffmann elimination, TBZ, Tetrabenazine, 未成年人, 烷基化过程, 烷基卤化物, 美国FDA, 药理活性, 霍夫曼