Details

Autor(en) / Beteiligte

• Xi, Wen Li
• Cai, Qian
• Tang, Yan Bo
• Sun, Hua
• Xiao, Zhi Yan

Titel

Design and synthesis of novel cytotoxic podophyllotoxin derivatives

Ist Teil von

• Chinese chemical letters, 2010-10, Vol.21 (10), p.1153-1156

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2010

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• In order to investigate the effect of different C4 linkage moieties on the cytotoxicity of podophyllotoxin derivatives, novel 4-N- and 4-C-substituted 4＇-O-demethylepipodophyllotoxin derivatives were designed and synthesized. All the compounds were tested against A549 and MCF-7 tumor cells in vitro, and six compounds showed significant cytotoxicity. The most active compound 9f was superior to GL-331, and exhibited potent cytotoxicity with IC50 value at 10^-7 mol/L level.