Chinese chemical letters, 2010-10, Vol.21 (10), p.1153-1156
2010
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Details
- Autor(en) / Beteiligte
- Titel
- Design and synthesis of novel cytotoxic podophyllotoxin derivatives
- Ist Teil von
- Chinese chemical letters, 2010-10, Vol.21 (10), p.1153-1156
- Ort / Verlag
- Elsevier B.V
- Erscheinungsjahr
- 2010
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- In order to investigate the effect of different C4 linkage moieties on the cytotoxicity of podophyllotoxin derivatives, novel 4-N- and 4-C-substituted 4＇-O-demethylepipodophyllotoxin derivatives were designed and synthesized. All the compounds were tested against A549 and MCF-7 tumor cells in vitro, and six compounds showed significant cytotoxicity. The most active compound 9f was superior to GL-331, and exhibited potent cytotoxicity with IC50 value at 10^-7 mol/L level.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1001-8417eISSN: 1878-5964DOI: 10.1016/j.cclet.2010.03.040Titel-ID: cdi_wanfang_journals_zghxkb201010004
- Format
- –
- Schlagworte
- C4-derivation, Cytotoxicity, IC50, MCF, Podophyllotoxin, 化合物, 细胞毒性, 联动效应, 肿瘤细胞, 设计合成, 鬼臼毒素衍生物