Details

Autor(en) / Beteiligte

• Zha, Xiao Ming
• Zhang, Fei Ran
• Shan, Jia Qi
• Zhang, Yi Hua
• Liu, Jun O.
• Sun, Hong Bin

Titel

Synthesis and evaluation of in vitro anticancer activity of novel solasodine derivatives

Ist Teil von

• Chinese chemical letters, 2010-09, Vol.21 (9), p.1087-1090

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2010

Quelle

ScienceDirect

Beschreibungen/Notizen

• Solasodine 11 is a steroidal alkaloid with various biological activities.Herein,8 novel solasodine derivatives were synthesized and their effect on prostate cancer cell proliferation was assessed in vitro.Significant improvement in antiproliferative activity was achieved among some of the synthetic analogs.In particular,19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line（IC50= 3.91μmol/L）.