Details

Autor(en) / Beteiligte

• Tang, Hui
• Zhou, You Jun
• Li, Yao Wu
• Lv, Jia Guo
• Zheng, Can Hui
• Chen, Jun
• Zhu, Ju

Titel

Design, synthesis and antifungal activities in vitro of novel tetralin compounds

Ist Teil von

• Chinese chemical letters, 2008-03, Vol.19 (3), p.264-268

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2008

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Novel chiral tetralin compounds were designed and synthesized, and their antifungal activities in vitro were tested. The results showed that all of target compounds had potent antifungal activities, and were stronger than that of control compounds tetrahydroisoquinolines. The binding model of lead molecules in the active site of CYP51 of Candida albicans showed that lead compound specifically interacted with the amino acids residues in the active site, without binding with the heme of CYP51, which was different from azole antifungal drugs. The present study might afford a novel lead molecule to develop non-azole CYP51 inhibitors of fungi.