Details

Autor(en) / Beteiligte

• Jang-Gi Choi Ji-Young Choi Su-Hyun Mun Ok-Hwa Kang Preeti Bharaj Dong-Won Shin Myong-Soo Chong Dong-Yeul Kwon

Titel

Antimicrobial activity and synergism of Sami-Hyanglyun-Hwan with ciprofloxacin against methicillin-resistant Staphylococcus aureus

Ist Teil von

• 亚太热带医药杂志（英文版）, 2015, Vol.8 (7), p.536-540

Ort / Verlag

Center of Excellence in Infectious Disease Research, Department of Biomedical Sciences, Paul L.Foster School of Medicine, Texas Tech University Health Sciences Center, ElPaso, TX 79905, USA%Department of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea%BK21 Plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea%Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, WonkwangOriental Medicines Research Institute, Jeonbuk 570-749,Korea%Center of Excellence in Infectious Disease Research, Department of Biomedical Sciences, Paul L.Foster School of Medicine, Texas Tech University Health Sciences Center, ElPaso, TX 79905, USA%Department of Oriental Medicine Resources, Sunchon National University, Jeonnam 540-742, Republic of Korea

Erscheinungsjahr

2015

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Objective: To investigate the antibacterial activity of SHHextracted with either water or ethanol against methicillin-resistant Staphylococcus aureus(MRSA) and combinatory antimicrobial effect with ciprofloxacin(CIP) by time kill assay and checkerboard dilution test. Methods: The antibacterial activity determined by broth dilution method indicated that the antibacterial activity of Sami-Hyanglyun-Hwan(SHH) water extract(SHHW) and SHH ethanol extract(SHHE) ranged from 250 to 2000 μg/m L and 125 to 1000 μg/m L against MRSA, respectively. Results: In the checkerboard method, the combinations of SHHE with CIP had a partial synergistic or synergistic effect against MRSA. The time-kill curves showed that a combined SHHE and CIP treatment reduced the bacterial counts dramatically after 24 h. Conclusions: The present study demonstrates the therapeutic ability of SHHE against MRSA infections.