Details

Autor(en) / Beteiligte

• Valter Donadon
• Massimiliano Balbi
• Pietro Casadn
• Alessandro Vario
• Alfredo Alberti

Titel

Association between hepatocellular carcinoma and type 2 diabetes mellitus in ltaly: Potential role of insulin

Ist Teil von

• 世界胃肠病学杂志（英文版）, 2008, Vol.14 (37), p.5695-5700

Ort / Verlag

Department of Medicine and Internal Medicine 3rd,Pordenone Hospital,Pordenone 33170,Italy%Department of Clinical and Experimental Medicine,University of Padova,Padova 35100,Italy

Erscheinungsjahr

2008

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• R5; AIM: TO investigate the relationships between Type 2 diabetes mellitus (DM2) and the risk of hepatocellular carcinoma (HCC).METHODS: We studied the association between DM2 and HCC in a large case-control study that enrolled 465 consecutive Caucasian patients with HCC (78.3% males,mean age 68.5 ± 8.9 years) compared with an age and sex matched control group of 490 subjects.RESULTS: Prevalence of DM2 was significantly higher in HCC patients (31.2% vs 12.7%; OR = 3.12,95% CI:2.22-4.43) and in HCC cases with alcohol abuse.DM2 has been diagnosed before the appearance of HCC in 84.1% of diabetic HCC subjects with mean duration of 141.5 mo,higher in cases treated with insulin than in those with oral antidiabetic agents (171.5 vs 118.7mo).Compared to controls,males DH2 with HCC were more frequently treated with insulin (38.1% vs 17.6%,P = 0.009) and with sulfonylurea with or without metformin than with diet with or without metformin (84% vs 68.3%,P = 0.049).CONCLUSION: DM2 in our patients is associated with a 3-fold increase risk of HCC.In most of ourcases DM2 pre-existed to HCC.Patients with DH2 and chronic liver disease,particularly insulin treated males,should be considered for HCC close surveillance programs.