Details

Autor(en) / Beteiligte

• Lin, Shao-Zhen
• Li, Bo
• Feng, Xi-Qiao

Titel

A dynamic cellular vertex model of growing epithelial tissues

Ist Teil von

• Acta mechanica Sinica, 2017-04, Vol.33 (2), p.250-259

Auflage

English ed.

Ort / Verlag

Beijing: The Chinese Society of Theoretical and Applied Mechanics, Institute of Mechanics, Chinese Academy of Sciences

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Intercellular interactions play a significant role in a wide range of biological functions and processes at both the cellular and tissue scales, for example, embryogenesis, organogenesis, and cancer invasion. In this paper, a dynamic cellular vertex model is presented to study the morphomechanics of a growing epithelial monolayer. The regulating role of stresses in soft tissue growth is revealed. It is found that the cells originating from the same parent cell in the monolayer can orchestrate into clustering patterns as the tissue grows. Collective cell migration exhibits a feature of spatial correlation across multiple cells. Dynamic intercellular interactions can engender a variety of distinct tissue behaviors in a social context. Uniform cell proliferation may render high and heterogeneous residual compressive stresses, while stress-regulated proliferation can effectively release the stresses, reducing the stress heterogeneity in the tissue. The results highlight the critical role of mechanical factors in the growth and morphogenesis of epithelial tissues and help understand the development and invasion of epithelial tumors.